PMID- 12497176
OWN - NLM
STAT- Publisher
LR  - 20191120
IS  - 1476-5608 (Electronic)
IS  - 1365-7852 (Linking)
VI  - 2
IP  - 5/6
DP  - 1999 Dec
TI  - Plasma steroid hormones, surgery for benign prostatic hyperplasia, and severe 
      lower urinary tract symptoms.
PG  - 285-289
AB  - Because benign prostatic hyperplasia (BPH) may be influenced by plasma steroid 
      hormones, we examined their relation in the Health Professionals Follow-up Study. 
      In 1993-1995, 18,000 cohort members provided blood. We selected as cases men who 
      had had surgery for BPH (n=174) or who scored 20-35 points (n=126) on the 
      American Urological Association index of severity of lower urinary tract 
      symptoms. Cases were matched by age to men who scored</=3 points and without an 
      enlarged prostate or elevated prostate-specific antigen. We estimated the odds 
      ratio (OR) of BPH surgery and severe lower urinary tract symptoms for plasma 
      testosterone (T), dihydrotestosterone (DHT), androstanediol glucuronide (AAG), 
      estradiol (E2), and sex hormone binding globulin (SHBG) in multivariable 
      conditional logistic regression models. Compared to the lowest tertiles, men in 
      the middle (OR=1.42) and top (OR=1.78) tertiles of AAG were at increased risk for 
      having either BPH surgery or severe lower urinary tract symptoms (P-trend=0.02). 
      Men in the middle (OR=0.58) and top (OR=0.60) tertiles of E2 were at lower risk. 
      T level was unrelated to surgery and symptoms. Our findings support opposing 
      roles for DHT, reflected by its metabolite AAG, and E2 in the etiology of BPH.
FAU - Platz, E A
AU  - Platz EA
AD  - Department of Nutrition, Harvard School of Public Health, Boston, Mass., USA.
FAU - Kawachi, I
AU  - Kawachi I
FAU - Rimm, E B
AU  - Rimm EB
FAU - Longcope, C
AU  - Longcope C
FAU - Stampfer, M J
AU  - Stampfer MJ
FAU - Willett, W C
AU  - Willett WC
FAU - Giovannucci, E
AU  - Giovannucci E
LA  - eng
PT  - Journal Article
PL  - England
TA  - Prostate Cancer Prostatic Dis
JT  - Prostate cancer and prostatic diseases
JID - 9815755
EDAT- 2002/12/24 04:00
MHDA- 2002/12/24 04:00
CRDT- 2002/12/24 04:00
PHST- 1999/06/25 00:00 [received]
PHST- 1999/11/03 00:00 [revised]
PHST- 1999/11/12 00:00 [accepted]
PHST- 2002/12/24 04:00 [pubmed]
PHST- 2002/12/24 04:00 [medline]
PHST- 2002/12/24 04:00 [entrez]
AID - 4500380 [pii]
AID - 10.1038/sj.pcan.4500380 [doi]
PST - ppublish
SO  - Prostate Cancer Prostatic Dis. 1999 Dec;2(5/6):285-289. doi: 
      10.1038/sj.pcan.4500380.