PMID- 12498220
OWN - NLM
STAT- MEDLINE
DCOM- 20030513
LR  - 20041117
IS  - 0344-0338 (Print)
IS  - 0344-0338 (Linking)
VI  - 198
IP  - 10
DP  - 2002
TI  - Identification of isolated and early prostatic adenocarcinoma in radical 
      prostatectomy specimens with correlation to biopsy cores: clinical and 
      pathogenetic significance.
PG  - 655-63
AB  - Prostatic adenocarcinoma (PAC) is a multifocal disease. In this study, we 
      identified isolated and small foci of PAC (ISPAC) in radical prostatectomy 
      specimens, described the histopathologic features, investigated their zonal 
      distribution in the prostate and their relationship with large tumor nodules, and 
      correlated the findings with those of preceding biopsy cores. One hundred and 
      thirty radical prostatectomy specimens performed for PAC or for urothelial 
      carcinoma of the urinary bladder with incidental PAC were reviewed for 
      identification of ISPAC. Prostates were serially sectioned in the horizontal 
      plane and submitted in toto for microscopic examination. ISPAC were defined as 
      foci of PAC measuring less than 3 mm in maximum diameter. There were 461 ISPAC 
      identified in 114 cases. They were distributed in the transitional zone (TZ) (18 
      foci), the apex (73 foci), the anterior horn of the non-TZ (NTZ) (118 foci), the 
      base (8 foci), and the remaining NTZ (244 foci). ISPAC usually consisted of 
      groups of small acini with a GS ranging from 2 to 7 (3 + 4). GSs of ISPAC 
      consisted of single grade or two consecutive grades equal to or lower than those 
      of the main PAC. ISPAC were more often located in close proximity to large tumor 
      nodules. The number of ISPAC increased with the tumor volume up to 3 cm3, then 
      decreased as the PAC became more extensive (p value = 0.02, statistically 
      significant). Prostates with NTZ PAC <1.5 cm3 and TZ PAC or prostates containing 
      4 or more than 4 ISPAC tended to be frequently associated with small foci of PAC 
      in biopsy cores In this study, we identified ISPAC that likely represent foci of 
      PAC in early development and account for the multicentricity and heterogeneity of 
      PAC. ISPAC in the NTZ were common and may account for small foci of PAC or atypia 
      in biopsy cores. Although these small foci of PAC or atypia in biopsy cores 
      without accompanying higher GS PAC were often associated with significant PAC, 
      they may also occasionally represent insignificant or vanishing PAC in subsequent 
      radical prostatectomies.
FAU - Mai, Kien T
AU  - Mai KT
AD  - Division of Anatomical Pathology, Department of Laboratory Medicine, The Ottawa 
      Hospital, Civic Campus, Ottawa, Ontario, Canada. ktmai@ottawahospital.on.ca
FAU - Landry, Denise C
AU  - Landry DC
FAU - Yazdi, Hossein M
AU  - Yazdi HM
FAU - Stinson, William A
AU  - Stinson WA
FAU - Perkins, D Garth
AU  - Perkins DG
FAU - Morash, Christopher
AU  - Morash C
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Pathol Res Pract
JT  - Pathology, research and practice
JID - 7806109
SB  - IM
MH  - Adenocarcinoma/*pathology/surgery
MH  - Aged
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Prostatectomy
MH  - Prostatic Intraepithelial Neoplasia/*pathology/surgery
MH  - Prostatic Neoplasms/*pathology/surgery
EDAT- 2002/12/25 04:00
MHDA- 2003/05/14 05:00
CRDT- 2002/12/25 04:00
PHST- 2002/12/25 04:00 [pubmed]
PHST- 2003/05/14 05:00 [medline]
PHST- 2002/12/25 04:00 [entrez]
AID - S0344-0338(04)70315-5 [pii]
AID - 10.1078/0344-0338-00317 [doi]
PST - ppublish
SO  - Pathol Res Pract. 2002;198(10):655-63. doi: 10.1078/0344-0338-00317.