PMID- 12498383
OWN - NLM
STAT- MEDLINE
DCOM- 20030530
LR  - 20071114
IS  - 1040-8401 (Print)
IS  - 1040-8401 (Linking)
VI  - 22
IP  - 3
DP  - 2002
TI  - Immune function of the decoy receptor osteoprotegerin.
PG  - 201-15
AB  - Osteoprotegerin (OPG) is a member of the tumor necrosis factor receptor (TNFR) 
      superfamily. OPG has an important function as a protector of bone, demonstrated 
      by the fact that OPG(-/-) mice have severe osteoporosis. OPG acts as a decoy 
      receptor, binding to RANK ligand (RANKL), thus preventing the interaction between 
      receptor activator of NF-kappaB (RANK) and RANKL. This interaction is required 
      for the development of functionally active osteoclasts. Osteoclasts are cells of 
      the monocytic lineage that are responsible for bone resportion. Furthermore, as 
      well as being an important player in the regulation of bone metabolism, OPG also 
      has a role in the regulation of the immune response. Dendritic cells (DCs) 
      express RANK and T cells express RANKL. The ligation of RANK by RANKL can 
      activate both T cells and DCs. Furthermore, both B cells and DCs secrete OPG, and 
      this secretion is regulated by the CD40 receptor. OPG(-/-) mice have B-cell 
      developmental defects. Also, DCs isolated from OPG(-/-) mice more efficiently 
      present antigen in vitro and secrete elevated amounts of inflammatory cytokines 
      when stimulated with bacterial products, or soluble RANKL in vitro. Taken 
      together, this suggests that OPG plays an important role in the immune response 
      regulating the interactions between T cells and DCs.
FAU - Bengtsson, Asa K
AU  - Bengtsson AK
AD  - Department of Microbiology, University of Washington, Box 357 330, Seattle, WA 
      98195, USA.
FAU - Ryan, Elizabeth J
AU  - Ryan EJ
LA  - eng
GR  - AI44257/AI/NIAID NIH HHS/United States
GR  - DE13061/DE/NIDCR NIH HHS/United States
GR  - RR00166/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Crit Rev Immunol
JT  - Critical reviews in immunology
JID - 8914819
RN  - 0 (Glycoproteins)
RN  - 0 (Hormones)
RN  - 0 (Osteoprotegerin)
RN  - 0 (Receptors, Cytoplasmic and Nuclear)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (TNFRSF11B protein, human)
SB  - IM
MH  - Animals
MH  - Bone Remodeling/immunology
MH  - Bone and Bones/*immunology/metabolism
MH  - Female
MH  - Glycoproteins/*immunology
MH  - Hematopoiesis/immunology
MH  - Hormones/immunology/metabolism
MH  - Humans
MH  - Male
MH  - Osteoprotegerin
MH  - Receptors, Cytoplasmic and Nuclear/*immunology
MH  - Receptors, Tumor Necrosis Factor
MH  - Reproduction/immunology
MH  - Signal Transduction/*immunology
RF  - 105
EDAT- 2002/12/25 04:00
MHDA- 2003/05/31 05:00
CRDT- 2002/12/25 04:00
PHST- 2002/12/25 04:00 [pubmed]
PHST- 2003/05/31 05:00 [medline]
PHST- 2002/12/25 04:00 [entrez]
PST - ppublish
SO  - Crit Rev Immunol. 2002;22(3):201-15.