PMID- 12499072
OWN - NLM
STAT- MEDLINE
DCOM- 20030519
LR  - 20190901
IS  - 0378-8741 (Print)
IS  - 0378-8741 (Linking)
VI  - 84
IP  - 1
DP  - 2003 Jan
TI  - Effects of wogonin, wogonoside, and 3,5,7,2',6'-pentahydroxyflavone on chemical 
      mediator production in peritoneal exduate cells and immunoglobulin E of rat 
      mesenteric lymph node lymphocytes.
PG  - 23-9
AB  - Wogonin (WG), wogonoside (WGS), and 3,5,7,2',6'-pentahydroxyl flavanone (PHF) 
      were isolated from Scutellaria baicalensis, and their effects on histamine, 
      leukotriene B(4) (LTB(4)), and immunoglobulin E (IgE) were examined in rats, 
      observing for a manifestation of a type I allergic reaction. WG and WGS in the 
      amounts of 10 and 100 microM were shown to markedly inhibit histamine release in 
      cells stimulated with calcium ionophore A23187 or compound 48/80. PHF exerted 
      inhibitory activity only at 100 microM. In the case of LTB(4), WG, WGS and PHF 
      markedly inhibited LTB(4) production at the concentration of 100 microM. We also 
      find that the increase in the IgE content induced by concanavalin A (ConA) was 
      alleviated in the presence WG and WGS, while the inhibitory effect of PHF was 
      much weaker. However, the magnitude of inhibitory effect observed on the content 
      of lipid peroxidation induced by ConA was in order of PHF > WG > WGS, with PHF 
      being the strongest. Interestingly, WG and WGS with the methoxyl group strongly 
      inhibited histamine and IgE production, whereas PHF with the hydroxyl group in 
      the B ring was much stronger than WG and WGS against lipid peroxidation. Based on 
      data, it was concluded that the flavonoid components, WG, WGS, and PHF, may block 
      a common pathway for the release of histamine and LTB(4), and that the IgE level 
      is responsible for the lipid peroxidation induced by ConA.
CI  - Copyright 2002 Elsevier Science Ireland Ltd.
FAU - Lim, Beong Ou
AU  - Lim BO
AD  - Department of Medical Nutrition, Graduate School of East-West Medical Science, 
      KyungHee University, 1 Hoeki-Dong, Dongdaemoon-ku, Seoul 130-701, South Korea. 
      beongou@khu.ac.kr
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (3,5,7,2',6'-pentahydroxyflavone)
RN  - 0 (Flavanones)
RN  - 0 (Flavonoids)
RN  - 0 (Glucosides)
RN  - 0 (Lipid Peroxides)
RN  - 1HGW4DR56D (Leukotriene B4)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 820484N8I3 (Histamine)
RN  - ETX4944Z3R (wogonoside)
RN  - POK93PO28W (wogonin)
SB  - IM
MH  - Animals
MH  - Ascitic Fluid/*cytology
MH  - *Flavanones
MH  - Flavonoids/*pharmacology
MH  - Glucosides/*pharmacology
MH  - Histamine/metabolism
MH  - Immunoglobulin E/*immunology
MH  - Leukotriene B4/metabolism
MH  - Lipid Peroxidation/drug effects
MH  - Lipid Peroxides/metabolism
MH  - Lymph Nodes/*drug effects/immunology
MH  - Lymphocytes/*drug effects/immunology
MH  - Mesentery/drug effects/immunology
MH  - Molecular Structure
MH  - Rats
MH  - Scutellaria baicalensis/chemistry
EDAT- 2002/12/25 04:00
MHDA- 2003/05/20 05:00
CRDT- 2002/12/25 04:00
PHST- 2002/12/25 04:00 [pubmed]
PHST- 2003/05/20 05:00 [medline]
PHST- 2002/12/25 04:00 [entrez]
AID - S037887410200257X [pii]
AID - 10.1016/s0378-8741(02)00257-x [doi]
PST - ppublish
SO  - J Ethnopharmacol. 2003 Jan;84(1):23-9. doi: 10.1016/s0378-8741(02)00257-x.