PMID- 12499711
OWN - NLM
STAT- MEDLINE
DCOM- 20030403
LR  - 20191210
IS  - 1015-9770 (Print)
IS  - 1015-9770 (Linking)
VI  - 15
IP  - 1-2
DP  - 2003
TI  - Polymorphisms of platelet adhesive receptors: do they play a role in primary 
      intracerebral hemorrhage?
PG  - 51-5
AB  - BACKGROUND: Several reports suggested that polymorphisms affecting the structure 
      or level of the main adhesive platelet glycoproteins (GPs) could behave as 
      genetic risk factors for arterial thrombotic disorders. However, very few reports 
      analyzed the significance of these polymorphisms in bleeding disorders. 
      Interestingly, one study suggested a role of the 807 C/T polymorphism of the 
      collagen receptor GP Ia in the severity of the bleeding manifestations in von 
      Willebrand disease. The aim of this study was to evaluate the role of frequent 
      polymorphisms affecting platelet GPs in primary intracerebral hemorrhage (PIH), 
      the third most frequent cause of cerebrovascular disorder. METHODS: We evaluated 
      the role of four putative prothrombotic polymorphisms: GP Ia [807 C/T, and human 
      platelet alloantigen system 5 (HPA-5)], GP Ibalpha (variable number of tandem 
      repeats), and GP IIIa (HPA-1) in 141 Caucasian patients diagnosed of PIH, 141 
      race-, age-, sex- and risk factor-matched controls, and 446 subjects from the 
      general population. RESULTS: The frequency of genotypes and alleles were similar 
      between patients and controls. CONCLUSIONS: Our results suggest that these 
      polymorphisms play a minor role in PIH.
CI  - Copyright 2003 S. Karger AG, Basel
FAU - Iniesta, Juan A
AU  - Iniesta J
AD  - Neurosurgery Division, Hospital Virgen de la Arrixaca, Murcia, Spain.
FAU - Corral, Javier
AU  - Corral J
FAU - Gonzalez-Conejero, Rocio
AU  - Gonzalez-Conejero R
FAU - Piqueras, Claudio
AU  - Piqueras C
FAU - Vicente, Vicente
AU  - Vicente V
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PL  - Switzerland
TA  - Cerebrovasc Dis
JT  - Cerebrovascular diseases (Basel, Switzerland)
JID - 9100851
RN  - 0 (Antigens, Human Platelet)
RN  - 0 (Genetic Markers)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Platelet Glycoprotein GPIb-IX Complex)
RN  - 0 (Platelet Membrane Glycoproteins)
RN  - 0 (adhesion receptor)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antigens, Human Platelet/genetics
MH  - Case-Control Studies
MH  - Cerebral Hemorrhage/epidemiology/genetics
MH  - Female
MH  - Gene Frequency/genetics
MH  - Genetic Markers/genetics
MH  - Genetic Predisposition to Disease/epidemiology/genetics
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Membrane Glycoproteins
MH  - Membrane Proteins/*genetics
MH  - Middle Aged
MH  - Patient Selection
MH  - Platelet Adhesiveness/*genetics
MH  - Platelet Glycoprotein GPIb-IX Complex
MH  - Platelet Membrane Glycoproteins/genetics
MH  - Polymorphism, Genetic/genetics
MH  - Prevalence
MH  - Risk Factors
MH  - Spain/epidemiology
MH  - Survival Analysis
EDAT- 2002/12/25 04:00
MHDA- 2003/04/04 05:00
CRDT- 2002/12/25 04:00
PHST- 2002/12/25 04:00 [pubmed]
PHST- 2003/04/04 05:00 [medline]
PHST- 2002/12/25 04:00 [entrez]
AID - 67126 [pii]
AID - 10.1159/000067126 [doi]
PST - ppublish
SO  - Cerebrovasc Dis. 2003;15(1-2):51-5. doi: 10.1159/000067126.