PMID- 12500983
OWN - NLM
STAT- MEDLINE
DCOM- 20030327
LR  - 20220310
IS  - 1526-484X (Print)
IS  - 1526-484X (Linking)
VI  - 12
IP  - 4
DP  - 2002 Dec
TI  - Metabolic response to provision of mixed protein-carbohydrate supplementation 
      during endurance exercise.
PG  - 384-97
AB  - The interaction of substrates and hormones in response to ingestion of intact 
      proteins during endurance exercise is unknown. This study characterized substrate 
      and hormone responses to supplementation during endurance exercise. Nine male 
      runners participated in 3 trials in which a non-fat (MILK), carbohydrate (CHO), 
      or placebo (PLA) drink was consumed during a 2-hour treadmill run at 65% VO2max. 
      Circulating levels of insulin, glucagon, epinephrine, norepinephrine, growth 
      hormone, testosterone, and cortisol were measured. Plasma substrates included 
      glucose, lactate, free fatty acids, and select amino acids. Except for insulin 
      and cortisol, hormones increased with exercise. While post-exercise insulin 
      concentrations declined similarly in all 3 trials, the glucagon increase was 
      greatest following MILK consumption. CHO blunted the post-exercise increase in 
      growth hormone compared to levels in MILK. Free fatty acids and plasma amino 
      acids also were responsive to nutritional supplementation with both CHO and MILK 
      attenuating the rise in free fatty acids compared to the increase observed in 
      PLA. Correspondingly, respiratory exchange ratio increased during CHO. Essential 
      amino acids increased significantly only after MILK and were either unchanged or 
      decreased in CHO. PLA was characterized by a decrease in branched-chain amino 
      acid concentrations. Modest nutritional supplementation in this study altered the 
      endocrine response as well as substrate availability and utilization following 
      and during an endurance run, respectively.
FAU - Miller, Sharon L
AU  - Miller SL
AD  - Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, 
      USA.
FAU - Maresh, Carl M
AU  - Maresh CM
FAU - Armstrong, Lawrence E
AU  - Armstrong LE
FAU - Ebbeling, Cara B
AU  - Ebbeling CB
FAU - Lennon, Shannon
AU  - Lennon S
FAU - Rodriguez, Nancy R
AU  - Rodriguez NR
LA  - eng
PT  - Clinical Trial
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Int J Sport Nutr Exerc Metab
JT  - International journal of sport nutrition and exercise metabolism
JID - 100939812
RN  - 0 (Amino Acids)
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Proteins)
RN  - 0 (Hormones)
RN  - 0 (Insulin)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 9007-92-5 (Glucagon)
SB  - IM
MH  - Adult
MH  - Amino Acids/blood
MH  - Blood Glucose/metabolism
MH  - Dietary Carbohydrates/administration & dosage/*metabolism
MH  - Dietary Proteins/administration & dosage/*metabolism
MH  - Dietary Supplements
MH  - *Energy Metabolism
MH  - Glucagon/blood
MH  - Hormones/*blood
MH  - Humans
MH  - Insulin/blood
MH  - Lactic Acid/blood
MH  - Male
MH  - Oxygen Consumption
MH  - Physical Endurance/*physiology
MH  - Respiration
MH  - *Running
EDAT- 2002/12/26 04:00
MHDA- 2003/03/28 05:00
CRDT- 2002/12/26 04:00
PHST- 2002/12/26 04:00 [pubmed]
PHST- 2003/03/28 05:00 [medline]
PHST- 2002/12/26 04:00 [entrez]
AID - 10.1123/ijsnem.12.4.384 [doi]
PST - ppublish
SO  - Int J Sport Nutr Exerc Metab. 2002 Dec;12(4):384-97. doi: 
      10.1123/ijsnem.12.4.384.