PMID- 12501657
OWN - NLM
STAT- MEDLINE
DCOM- 20030110
LR  - 20061115
IS  - 0559-7765 (Print)
IS  - 0559-7765 (Linking)
VI  - 29
IP  - 4
DP  - 1998 Oct
TI  - [11 beta-Hydroxysteroid dehydrogenase].
PG  - 301-6
AB  - There are two types of 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD). 11 
      beta-HSD 1 is an oxoreductase interconverting biologically active cortisol and 
      inactive cortisone. 11 beta-HSD 2 is an exclusive oxidase only converting 
      cortisol to cortisone. It has been recognized that 11 beta-HSD 2 confers the 
      specificity of mineralocorticoid receptor in the kidney and protects the fetus 
      from high levels of maternal glucocorticoids in the placenta. Lack or malfunction 
      of this enzyme could result in the development of apparent mineralocorticoid 
      excess syndrome and intrauterine growth retardation of the fetus. 11 beta-HSD is 
      possibly involved in a number of other physiological and pathological conditions 
      such as stress, hypertension, diabetes mellitus and neurodegenerative disorders. 
      The functions of 11 beta-HSD 1 are not very well understood.
FAU - Sun, G
AU  - Sun G
AD  - Department of Neurobiology, Second Military Medical University, Shanghai 200433.
FAU - Li, P
AU  - Li P
FAU - Yang, K P
AU  - Yang KP
FAU - Challis, J R
AU  - Challis JR
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - China
TA  - Sheng Li Ke Xue Jin Zhan
JT  - Sheng li ke xue jin zhan [Progress in physiology]
JID - 20730140R
RN  - 0 (Glucocorticoids)
RN  - 0 (Mineralocorticoids)
RN  - EC 1.1.- (Hydroxysteroid Dehydrogenases)
RN  - EC 1.1.1.146 (11-beta-Hydroxysteroid Dehydrogenase Type 2)
RN  - EC 1.1.1.146 (HSD11B2 protein, human)
SB  - IM
MH  - 11-beta-Hydroxysteroid Dehydrogenase Type 2
MH  - Animals
MH  - Glucocorticoids/*metabolism
MH  - Humans
MH  - Hydroxysteroid Dehydrogenases/*physiology
MH  - Mineralocorticoids/*metabolism
RF  - 19
EDAT- 2002/12/28 04:00
MHDA- 2003/01/11 04:00
CRDT- 2002/12/28 04:00
PHST- 2002/12/28 04:00 [pubmed]
PHST- 2003/01/11 04:00 [medline]
PHST- 2002/12/28 04:00 [entrez]
PST - ppublish
SO  - Sheng Li Ke Xue Jin Zhan. 1998 Oct;29(4):301-6.