PMID- 12503764
OWN - NLM
STAT- MEDLINE
DCOM- 20030402
LR  - 20161018
IS  - 0730-7268 (Print)
IS  - 0730-7268 (Linking)
VI  - 22
IP  - 1
DP  - 2003 Jan
TI  - Dietary accumulation of perfluorinated acids in juvenile rainbow trout 
      (Oncorhynchus mykiss).
PG  - 189-95
AB  - Perfluorinated acids (PFAs) recently have emerged as persistent global 
      contaminants after their detection in wildlife and humans from various geographic 
      locations. The highest concentrations of perfluorooctane sulfonate are 
      characteristically observed in high trophic level organisms, indicating that PFAs 
      may have a significant bioaccumulation potential. To examine this phenomenon 
      quantitatively, we exposed juvenile rainbow trout (Oncorhynchus mykiss) 
      simultaneously to a homologous series of perfluoroalkyl carboxylates and 
      sulfonates for 34 d in the diet, followed by a 41-d depuration period. Carcass 
      and liver concentrations were determined by using liquid chromatography-tandem 
      mass spectrometry, and kinetic rates were calculated to determine 
      compound-specific bioaccumulation parameters. Depuration rate constants ranged 
      from 0.02 to 0.23/d, and decreased as the length of the fluorinated chain 
      increased. Assimilation efficiency was greater than 50% for all test compounds, 
      indicating efficient absorption from food. Bioaccumulation factors (BAFs) ranged 
      from 0.038 to 1.0 and increased with length of the perfluorinated chain; however, 
      BAFs were not statistically greater than 1 for any PFA. Sulfonates bioaccumulated 
      to a greater extent than carboxylates of equivalent perfluoroalkyl chain length, 
      indicating that hydrophobicity is not the sole determinant of PFA accumulation 
      potential and that the acid function must be considered. Dietary exposure will 
      not result in biomagnification of PFAs in juvenile trout, but extrapolation of 
      these bioaccumulation parameters to larger fish and homeothermic organisms should 
      not be performed.
FAU - Martin, Jonathan W
AU  - Martin JW
AD  - University of Guelph, Department of Environmental Biology, Bovey Building, 
      Guelph, Ontario N1G 2W1, Canada. jmartin@chem.utoronto.ca
FAU - Mabury, Scott A
AU  - Mabury SA
FAU - Solomon, Keith R
AU  - Solomon KR
FAU - Muir, Derek C G
AU  - Muir DC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Environ Toxicol Chem
JT  - Environmental toxicology and chemistry
JID - 8308958
RN  - 0 (Acids)
RN  - 0 (Fluorocarbons)
RN  - 0 (Surface-Active Agents)
RN  - 0 (Water Pollutants, Chemical)
SB  - IM
CIN - Environ Toxicol Chem. 2013 Nov;32(11):2421-3. PMID: 24115121
MH  - Acids/pharmacokinetics
MH  - Animal Feed
MH  - Animals
MH  - Chromatography, Liquid
MH  - Diet
MH  - Fluorocarbons/*pharmacokinetics
MH  - Kinetics
MH  - Mass Spectrometry
MH  - Oncorhynchus mykiss/*physiology
MH  - Surface-Active Agents/*pharmacokinetics
MH  - Tissue Distribution
MH  - Water Pollutants, Chemical/*pharmacokinetics
EDAT- 2002/12/31 04:00
MHDA- 2003/04/04 05:00
CRDT- 2002/12/31 04:00
PHST- 2002/12/31 04:00 [pubmed]
PHST- 2003/04/04 05:00 [medline]
PHST- 2002/12/31 04:00 [entrez]
PST - ppublish
SO  - Environ Toxicol Chem. 2003 Jan;22(1):189-95.