PMID- 12503765
OWN - NLM
STAT- MEDLINE
DCOM- 20030402
LR  - 20161018
IS  - 0730-7268 (Print)
IS  - 0730-7268 (Linking)
VI  - 22
IP  - 1
DP  - 2003 Jan
TI  - Bioconcentration and tissue distribution of perfluorinated acids in rainbow trout 
      (Oncorhynchus mykiss).
PG  - 196-204
AB  - Rainbow trout (Oncorhynchus mykiss) were exposed simultaneously to a homologous 
      series of perfluoroalkyl carboxylates and sulfonates in a flow-through system to 
      determine compound-specific tissue distribution and bioconcentration parameters 
      for perfluorinated acids (PFAs). In general, PFAs accumulated to the greatest 
      extent in blood > kidney > liver > gall bladder. Carboxylates and sulfonates with 
      perfluoroalkyl chain lengths shorter than seven and six carbons, respectively, 
      could not be detected in most tissues and were considered to have insignificant 
      bioconcentration factors (BCFs). For detectable PFAs, carcass BCFs increased with 
      increasing length of the perfluoroalkyl chain, ranging from 4.0 to 23,000, based 
      on wet weight concentrations. Carboxylate carcass BCFs increased by a factor of 
      eight for each additional carbon in the perfluoroalkyl chain between 8 and 12 
      carbons, but this relationship deviated from linearity for the longest PFA 
      tested, possibly because of decreased gill permeability. In general, half-lives 
      (3.9-28 d) and uptake rates (0.053-1.700 L/kg/d) also increased with increasing 
      length of the perfluoroalkyl chain in all tissues. Sulfonates had greater BCFs, 
      half-lives, and rates of uptake than the corresponding carboxylate of equal 
      perfluoroalkyl chain length, indicating that hydrophobicity, as predicted by the 
      critical micelle concentration, is not the only determinant of PFA 
      bioaccumulation potential and that the acid function must be considered.
FAU - Martin, Jonathan W
AU  - Martin JW
AD  - University of Guelph, Department of Environmental Biology, Bovey Building, 
      Guelph, Ontario N1G 2W1, Canada. jmartin@chem.utoronto.ca
FAU - Mabury, Scott A
AU  - Mabury SA
FAU - Solomon, Keith R
AU  - Solomon KR
FAU - Muir, Derek C G
AU  - Muir DC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Environ Toxicol Chem
JT  - Environmental toxicology and chemistry
JID - 8308958
RN  - 0 (Acids)
RN  - 0 (Fluorocarbons)
RN  - 0 (Water Pollutants, Chemical)
SB  - IM
CIN - Environ Toxicol Chem. 2013 Nov;32(11):2421-3. PMID: 24115121
MH  - Acids/pharmacokinetics
MH  - Animals
MH  - Fluorocarbons/*pharmacokinetics
MH  - Half-Life
MH  - Kinetics
MH  - Oncorhynchus mykiss/*physiology
MH  - Tissue Distribution
MH  - Water Pollutants, Chemical/*pharmacokinetics
EDAT- 2002/12/31 04:00
MHDA- 2003/04/04 05:00
CRDT- 2002/12/31 04:00
PHST- 2002/12/31 04:00 [pubmed]
PHST- 2003/04/04 05:00 [medline]
PHST- 2002/12/31 04:00 [entrez]
PST - ppublish
SO  - Environ Toxicol Chem. 2003 Jan;22(1):196-204.