PMID- 12504576
OWN - NLM
STAT- MEDLINE
DCOM- 20030508
LR  - 20190714
IS  - 0042-6822 (Print)
IS  - 0042-6822 (Linking)
VI  - 304
IP  - 2
DP  - 2002 Dec 20
TI  - Association of primate T-cell lymphotropic virus infection of pig-tailed macaques 
      with high mortality.
PG  - 364-78
AB  - Natural infection of humans with human T-cell lymphotropic virus type I (HTLV-I) 
      and of old world nonhuman primates with the simian counterpart, STLV-I, is 
      associated with development of neoplastic disease in a small percentage of 
      individuals after long latent periods. HTLV-I is also the etiologic agent of a 
      more rapidly progressive neurologic disease, HTLV-I-associated 
      myelopathy/tropical spastic paraparesis (HAM/TSP). Macaques have been used 
      experimentally in studies to evaluate HTLV-I candidate vaccines for efficacy, but 
      no evidence of disease was observed. Here we report experimental infection of 
      pig-tailed macaques with STLV-I(sm) and HTLV-I(ACH), both of which were 
      associated with a disease syndrome characterized by rapid onset, hypothermia, 
      lethargy, and death within hours to days. Other pathologic sequelae included 
      diarrhea, rash, bladder dysfunction, weight loss, and, in one animal, 
      arthropathy. Both retroviruses were detected in the central nervous systems of 
      some animals, either by culture or by direct antigen capture for p19 Gag in 
      cerebrospinal fluid. Although virus was recovered throughout infection from 
      peripheral blood mononuclear cells (PBMC), all infected macaques maintained low 
      antiviral antibody titers and stable proviral burdens, which generally ranged 
      between 10 and 100 copies per 10(6) PBMC. However, of 13 macaques infected with 
      HTLV-I(ACH) or STLV-I(sm), seven animals (54%) died between 35 weeks and 412 
      years after infection. This unexpected high mortality within a relatively short 
      time suggests that infection of pig-tailed macaques might be a useful model for 
      studying immune responses to and pathologic events resulting from HTLV-I 
      infection.
CI  - Copyright 2002 Elsevier Science (USA)
FAU - McGinn, Therese M
AU  - McGinn TM
AD  - Department of Microbiology, University of Alabama School of Medicine, Brimingham 
      35294, USA.
FAU - Tao, Binli
AU  - Tao B
FAU - Cartner, Samuel
AU  - Cartner S
FAU - Schoeb, Trenton
AU  - Schoeb T
FAU - Davis, Ian
AU  - Davis I
FAU - Ratner, Lee
AU  - Ratner L
FAU - Fultz, Patricia N
AU  - Fultz PN
LA  - eng
GR  - AI27767/AI/NIAID NIH HHS/United States
GR  - CA67386/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Virology
JT  - Virology
JID - 0110674
RN  - 0 (Antibodies, Viral)
SB  - IM
MH  - Animals
MH  - Antibodies, Viral/blood
MH  - Deltaretrovirus Infections/immunology/*mortality/pathology
MH  - Disease Models, Animal
MH  - HTLV-I Infections/immunology/*mortality/pathology
MH  - Humans
MH  - Lymphocytes/virology
MH  - Macaca nemestrina
MH  - *Simian T-lymphotropic virus 1
MH  - Viral Load
EDAT- 2002/12/31 04:00
MHDA- 2003/05/09 05:00
CRDT- 2002/12/31 04:00
PHST- 2002/12/31 04:00 [pubmed]
PHST- 2003/05/09 05:00 [medline]
PHST- 2002/12/31 04:00 [entrez]
AID - S0042682202917058 [pii]
AID - 10.1006/viro.2002.1705 [doi]
PST - ppublish
SO  - Virology. 2002 Dec 20;304(2):364-78. doi: 10.1006/viro.2002.1705.