PMID- 12505265
OWN - NLM
STAT- MEDLINE
DCOM- 20030115
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 138
IP  - 2
DP  - 2002 Oct 15
TI  - Trisomy 21 as the only recurrent chromosomal anomaly in a clinically aggressive 
      ovarian carcinoma.
PG  - 165-8
AB  - A case of a highly aggressive grade III poorly differentiated serous 
      adenocarcinoma of the ovary was determined to exhibit trisomy 21 as the sole 
      chromosomal abnormality. To eliminate the possibility that this trisomy was 
      constitutional, the patient's blood cells were subjected to locus specific 
      21q22.13 approximately q22.2 chromosome probe using fluorescence in situ 
      hybridization (FISH). Concurrently, using FISH and the same probe the tumor 
      tissue was also tested. We discovered that 48% of the cells of the tumor tissue 
      either had trisomy or tetrasomy of chromosome 21. Two normal signal patterns for 
      chromosome 21 in blood and absence of Down morphology in the patient confirmed 
      the presence of trisomy to be limited to the tumor tissue. To the best of our 
      knowledge, this is the only case where trisomy 21 was shown to be the sole 
      chromosomal anomaly in a serous carcinoma of the ovary. Tumorigenesis in 
      gynecologic malignancies is discussed in the light of oncogenes present on 
      chromosome 21.
FAU - Faruqi, Shamim A
AU  - Faruqi SA
AD  - Department of OB/GYN, Crozer-Chester Medical Center, Upland, PA, USA. 
      gynoncob@aol.com
FAU - Noumoff, Mathew J
AU  - Noumoff MJ
FAU - Deger, Randolph B
AU  - Deger RB
FAU - Jalal, Syed M
AU  - Jalal SM
FAU - Antoniades, Kristina
AU  - Antoniades K
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Adenocarcinoma/genetics/pathology
MH  - Down Syndrome/*genetics
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Middle Aged
MH  - Ovarian Neoplasms/*genetics/*pathology
MH  - Peritoneal Neoplasms/genetics/secondary
MH  - Trisomy/*genetics
EDAT- 2002/12/31 04:00
MHDA- 2003/01/16 04:00
CRDT- 2002/12/31 04:00
PHST- 2002/12/31 04:00 [pubmed]
PHST- 2003/01/16 04:00 [medline]
PHST- 2002/12/31 04:00 [entrez]
AID - S0165460802005964 [pii]
AID - 10.1016/s0165-4608(02)00596-4 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2002 Oct 15;138(2):165-8. doi: 
      10.1016/s0165-4608(02)00596-4.