PMID- 12505266
OWN - NLM
STAT- MEDLINE
DCOM- 20030115
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 138
IP  - 2
DP  - 2002 Oct 15
TI  - Cryptic translocation of PML/RARA on 17q. A rare event in acute promyelocytic 
      leukemia.
PG  - 169-73
AB  - Cryptic translocations in acute promyelocytic leukemia are rare. Usually the gene 
      fusion PML/RARA is located on chromosome 15. Combined cytogenetic, fluorescence 
      in situ hybridization (FISH), and molecular (polymerase chain reaction [PCR]) 
      analysis were employed for the diagnosis and precise localization of the fusion 
      gene. Conventional cytogenetics showed a normal karyotype; PCR showed a typical 
      PML/RARA rearrangement in exon 1. FISH analysis revealed that a submicroscopic 
      part of chromosome 15 had been inserted into 17q. This case adds further 
      information on alternative ways of rearrangement of the PML/RARA genes, possibly 
      correlated with all-trans retinoic acid resistance.
FAU - Zaccaria, Alfonso
AU  - Zaccaria A
AD  - Hematology Unit, Santa Maria delle Croci Hospital, Viale Randi 5, 48100, Ravenna, 
      Italy.
FAU - Valenti, Anna
AU  - Valenti A
FAU - Toschi, Mila
AU  - Toschi M
FAU - Salvucci, Marzia
AU  - Salvucci M
FAU - Cipriani, Raffaella
AU  - Cipriani R
FAU - Ottaviani, Emanuela
AU  - Ottaviani E
FAU - Martinelli, Giovanni
AU  - Martinelli G
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Oncogene Proteins, Fusion)
RN  - 0 (promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein)
SB  - IM
CIN - Cancer Genet Cytogenet. 2004 Jan 15;148(2):176-7. PMID: 14734236
MH  - Adult
MH  - Chromosomes, Human, Pair 17/*genetics
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Leukemia, Promyelocytic, Acute/*genetics
MH  - Neoplasm Proteins/*genetics
MH  - Oncogene Proteins, Fusion/*genetics
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Translocation, Genetic/*genetics
EDAT- 2002/12/31 04:00
MHDA- 2003/01/16 04:00
CRDT- 2002/12/31 04:00
PHST- 2002/12/31 04:00 [pubmed]
PHST- 2003/01/16 04:00 [medline]
PHST- 2002/12/31 04:00 [entrez]
AID - S0165460802005848 [pii]
AID - 10.1016/s0165-4608(02)00584-8 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2002 Oct 15;138(2):169-73. doi: 
      10.1016/s0165-4608(02)00584-8.