PMID- 12507148
OWN - NLM
STAT- MEDLINE
DCOM- 20030116
LR  - 20041117
IS  - 0022-3085 (Print)
IS  - 0022-3085 (Linking)
VI  - 97
IP  - 6
DP  - 2002 Dec
TI  - Malignant rhabdoid meningioma arising in the setting of preexisting 
      ganglioglioma: a diagnosis supported by fluorescence in situ hybridization. Case 
      report.
PG  - 1450-5
AB  - A highly malignant brain neoplasm with rhabdoid morphological features emerged in 
      the bed of a subtotally resected ganglioglioma in a 54-year-old retired nuclear 
      submarine officer. A combined application of neuroimaging, immunohistochemical 
      studies, electron microscopy, and fluorescence in situ hybridization (FISH) was 
      used to establish the morphological identity of the tumor. The rhabdoid 
      appearance of the tumor cells indicated either an especially malignant variant of 
      rhabdoid meningioma or an atypical teratoid/rhabdoid tumor with an unusually late 
      onset. Whereas immunohistochemical studies and electron microscopy could only be 
      used to narrow down the differential diagnosis, FISH revealed loss of one copy of 
      NF2 with preservation of the INI1 region on 22q, thus establishing the identity 
      of the tumor.
FAU - Bannykh, Sergei I
AU  - Bannykh SI
AD  - Department of Pathology, University of California at San Diego, La Jolla, 
      California 92093-0612, USA. bannykh@scripps.edu
FAU - Perry, Arie
AU  - Perry A
FAU - Powell, Henry C
AU  - Powell HC
FAU - Hill, Ashley
AU  - Hill A
FAU - Hansen, Lawrence A
AU  - Hansen LA
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - J Neurosurg
JT  - Journal of neurosurgery
JID - 0253357
RN  - 0 (DNA, Neoplasm)
SB  - IM
MH  - DNA, Neoplasm/analysis
MH  - Ganglioglioma/genetics/*pathology
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Inclusion Bodies/pathology/ultrastructure
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Meningeal Neoplasms/genetics/*pathology
MH  - Meningioma/genetics/*pathology
MH  - Microscopy, Electron
MH  - Middle Aged
MH  - Neurofibromatosis 2/genetics/pathology
MH  - Rhabdoid Tumor/genetics/*pathology
EDAT- 2003/01/01 04:00
MHDA- 2003/01/17 04:00
CRDT- 2003/01/01 04:00
PHST- 2003/01/01 04:00 [pubmed]
PHST- 2003/01/17 04:00 [medline]
PHST- 2003/01/01 04:00 [entrez]
AID - 10.3171/jns.2002.97.6.1450 [doi]
PST - ppublish
SO  - J Neurosurg. 2002 Dec;97(6):1450-5. doi: 10.3171/jns.2002.97.6.1450.