PMID- 12507560
OWN - NLM
STAT- MEDLINE
DCOM- 20030813
LR  - 20191106
IS  - 1044-579X (Print)
IS  - 1044-579X (Linking)
VI  - 13
IP  - 1
DP  - 2003 Feb
TI  - The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) 
      degradation, and cancer pathogenesis.
PG  - 83-9
AB  - Recently, work on the mechanism of action of the von Hippel-Lindau tumour 
      suppressor protein (pVHL) and studies on hypoxic gene regulation have converged, 
      providing insights into both cellular oxygen sensing and cancer pathogenesis. 
      pVHL is the recognition component of the E3-ubiquitin ligase complex involved in 
      the degradation of hypoxia-inducible factor-1 (HIF) alpha-subunits, a process 
      regulated by oxygen availability and blocked by disease causing pVHL mutations. 
      In normoxic cells, pVHL targeting of HIF-alpha subunits follows hydroxylation of 
      critical HIF prolyl residues by a group of oxygen, 2-oxoglutarate- and 
      iron-dependent enzymes. In this review, we outline current understanding of 
      HIF/pVHL/prolyl hydroxylase pathway and consider the implications for 
      VHL-associated cancer.
CI  - Copyright 2002 Elsevier Science Ltd.
FAU - Pugh, Christopher William
AU  - Pugh CW
AD  - Oxygen-sensing Group, Henry Wellcome Building for Genomic Medicine, University of 
      Oxford, Roosevelt Drive, Headington, Oxford OX3 7BN, UK. cpugh@well.ox.ac.uk
FAU - Ratcliffe, Peter John
AU  - Ratcliffe PJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Semin Cancer Biol
JT  - Seminars in cancer biology
JID - 9010218
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (HIF1A protein, human)
RN  - 0 (Hypoxia-Inducible Factor 1)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Transcription Factors)
RN  - 0 (Tumor Suppressor Proteins)
RN  - EC 2.3.2.27 (Ubiquitin-Protein Ligases)
RN  - EC 2.3.2.27 (Von Hippel-Lindau Tumor Suppressor Protein)
RN  - EC 6.- (Ligases)
RN  - EC 6.3.2.- (VHL protein, human)
SB  - IM
MH  - DNA-Binding Proteins/*metabolism
MH  - Gene Expression Regulation/physiology
MH  - Genes, Tumor Suppressor/physiology
MH  - Humans
MH  - Hypoxia/genetics/metabolism
MH  - Hypoxia-Inducible Factor 1
MH  - Hypoxia-Inducible Factor 1, alpha Subunit
MH  - Ligases/*metabolism
MH  - Neoplasms/*physiopathology
MH  - Nuclear Proteins/*metabolism
MH  - *Transcription Factors
MH  - *Tumor Suppressor Proteins
MH  - *Ubiquitin-Protein Ligases
MH  - Von Hippel-Lindau Tumor Suppressor Protein
MH  - von Hippel-Lindau Disease/genetics/physiopathology
RF  - 78
EDAT- 2003/01/01 04:00
MHDA- 2003/08/14 05:00
CRDT- 2003/01/01 04:00
PHST- 2003/01/01 04:00 [pubmed]
PHST- 2003/08/14 05:00 [medline]
PHST- 2003/01/01 04:00 [entrez]
AID - S1044579X02001037 [pii]
AID - 10.1016/s1044-579x(02)00103-7 [doi]
PST - ppublish
SO  - Semin Cancer Biol. 2003 Feb;13(1):83-9. doi: 10.1016/s1044-579x(02)00103-7.