PMID- 12507820
OWN - NLM
STAT- MEDLINE
DCOM- 20040106
LR  - 20190906
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 64
IP  - 1
DP  - 2003 Jan
TI  - The association of class I HLA alleles and antibody levels after a single dose of 
      measles vaccine.
PG  - 103-9
AB  - Despite the success of the current measles vaccine in controlling disease in 
      industrialized countries, the importance of vaccine failure has become 
      increasingly apparent. Our objective was to determine if associations exist 
      between seronegativity after measles vaccination and class I human leukocyte 
      antigen (HLA) alleles. We undertook a cross-sectional observational study in 
      Rochester, Minnesota, with 242 school-age children previously recruited from a 
      communitywide seroprevalence study. We studied two groups of subjects: 72 were 
      seronegative (EIA < or =0.8 after a single dose of measles vaccine) and 170 were 
      seropositive (enzyme immunoassy [EIA] > or =1.0 after one dose). We used the 
      resources of Mayo Clinic's tissue typing laboratory for serotyping class I HLA-A 
      and HLA-B alleles via microlymphocytotoxicity assays. We found no statistically 
      significant associations with class I HLA-A but did find associations with class 
      I HLA-B, which includes alleles associated with seronegativity (B8, B13, and B44) 
      and those associated with seropositivity (B7 and B51). Elucidation of the 
      specific peptide-HLA complex interactions that lead to varying or failed immune 
      responses may provide fertile groundwork for improved vaccines that can overcome 
      limitations of the current live, attenuated measles vaccine.
FAU - Jacobson, Robert M
AU  - Jacobson RM
AD  - Department of Pediatric and Adolescent MedicineMayo Clinic, Rochester, MN 55903, 
      USA. jacobson.robert@mayo.edu
FAU - Poland, Gregory A
AU  - Poland GA
FAU - Vierkant, Robert A
AU  - Vierkant RA
FAU - Pankratz, V Shane
AU  - Pankratz VS
FAU - Schaid, Daniel J
AU  - Schaid DJ
FAU - Jacobsen, Steven J
AU  - Jacobsen SJ
FAU - Sauver, Jennifer St
AU  - Sauver JS
FAU - Moore, S Breanndan
AU  - Moore SB
LA  - eng
GR  - M01-RR-00585-25/RR/NCRR NIH HHS/United States
GR  - N01-AI-45240/AI/NIAID NIH HHS/United States
GR  - R01-2AI-33144/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Antibodies, Viral)
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Measles Vaccine)
SB  - IM
MH  - *Alleles
MH  - Antibodies, Viral/biosynthesis/*blood
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - HLA Antigens/genetics
MH  - Histocompatibility Antigens Class I/genetics/*immunology
MH  - Humans
MH  - Male
MH  - Measles Vaccine/*immunology
EDAT- 2003/01/01 04:00
MHDA- 2004/01/07 05:00
CRDT- 2003/01/01 04:00
PHST- 2003/01/01 04:00 [pubmed]
PHST- 2004/01/07 05:00 [medline]
PHST- 2003/01/01 04:00 [entrez]
AID - S0198885902007413 [pii]
AID - 10.1016/s0198-8859(02)00741-3 [doi]
PST - ppublish
SO  - Hum Immunol. 2003 Jan;64(1):103-9. doi: 10.1016/s0198-8859(02)00741-3.