PMID- 12507822
OWN - NLM
STAT- MEDLINE
DCOM- 20040106
LR  - 20211203
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 64
IP  - 1
DP  - 2003 Jan
TI  - Clinical and genetic heterogeneity in Mexican patients with ulcerative colitis.
PG  - 119-23
AB  - Ulcerative colitis (UC) is an inflammatory bowel disease of unknown etiology. 
      Genetic factors implied on its onset and severity may include genes located 
      within the class II major histocompatibility complex (MHC) region. The aim of 
      this study was to determine the relationship between human leukocyte antigen 
      (HLA)-DRB1 alleles with the clinical disease patterns of UC in Mexican Mestizo 
      patients. High-resolution HLA typing was performed by polymerase chain 
      reaction-sequence specific oligonucleotide (PCR)-SSO reverse dot blot and 
      PCR-single-strand polymorphism in 67 patients with UC and 99 ethnically matched 
      healthy controls. UC patients overall showed an increased frequency of HLA-DR1 as 
      compared with healthy controls (17.1% versus 5%, [pC = 0.003, OR = 3.9]). 
      Patients with extensive colitis showed increased frequencies of HLA-DR1 (pC = 1 x 
      10(-10), OR = 13.9), HLA-DRB1*0103 (pC = 1 x 10(-3), OR = 21.7), HLA-DRB1*0102 
      (pC = 0.007, OR = undetermined), and HLA-DR15 (pC = 1 x 10(-3), OR = 8.5) when 
      compared with healthy controls. We also found a statistically increased frequency 
      of HLA-DR15 in UC patients with extensive colitis compared with UC patients with 
      only distal colitis (18.7% versus 1.8%, pC = 0.03; OR = 12.2). When patients who 
      underwent proctocolectomy were compared with those who did not, an increased 
      frequency of HLA-DRB1*0103 was observed (21.8% versus 4.9%; pC = 0.03; OR = 5.4; 
      95% confidence interval, 1.39-21.93). Also, patients with proctocolectomy showed 
      increased frequencies of HLA-DR1 (pC = 1 x 10(-3), OR = 24.2) and HLA-DRB1*0103 
      (pC = 1 x 10(-3), OR = 50.6) when compared with healthy controls. We concluded 
      that HLA-DR1 is associated with genetic susceptibility to UC in the Mexican 
      Mestizo population. HLA-DR15 distinguishes a subgroup of patients with extensive 
      colitis and the HLA-DRB1*0103 allele distinguishes a subgroup of severe form of 
      disease that might require surgical management.
FAU - Yamamoto-Furusho, Jesus K
AU  - Yamamoto-Furusho JK
AD  - Department of Gastroenterology, Instituto Nacional de Ciencias Medicas y 
      Nutricion Salvador Zubiran, Tlalpan, Mexico.
FAU - Uscanga, Luis F
AU  - Uscanga LF
FAU - Vargas-Alarcon, Gilberto
AU  - Vargas-Alarcon G
FAU - Ruiz-Morales, Jorge A
AU  - Ruiz-Morales JA
FAU - Higuera, Lorena
AU  - Higuera L
FAU - Cutino, Teresa
AU  - Cutino T
FAU - Rodriguez-Perez, Jose Manuel
AU  - Rodriguez-Perez JM
FAU - Villarreal-Garza, Cynthia
AU  - Villarreal-Garza C
FAU - Granados, Julio
AU  - Granados J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Adult
MH  - Colitis, Ulcerative/epidemiology/*genetics
MH  - Disease Susceptibility
MH  - Ethnicity/genetics
MH  - Female
MH  - *Genetic Heterogeneity
MH  - Genetic Predisposition to Disease/*genetics
MH  - HLA-DR Antigens/*genetics
MH  - Haplotypes
MH  - Humans
MH  - Male
MH  - Mexico/epidemiology
EDAT- 2003/01/01 04:00
MHDA- 2004/01/07 05:00
CRDT- 2003/01/01 04:00
PHST- 2003/01/01 04:00 [pubmed]
PHST- 2004/01/07 05:00 [medline]
PHST- 2003/01/01 04:00 [entrez]
AID - S0198885902007723 [pii]
AID - 10.1016/s0198-8859(02)00772-3 [doi]
PST - ppublish
SO  - Hum Immunol. 2003 Jan;64(1):119-23. doi: 10.1016/s0198-8859(02)00772-3.