PMID- 12507823
OWN - NLM
STAT- MEDLINE
DCOM- 20040106
LR  - 20220410
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 64
IP  - 1
DP  - 2003 Jan
TI  - Allelic distribution of human leukocyte antigen in Iranian patients with 
      pulmonary tuberculosis.
PG  - 124-9
AB  - There is convincing evidence for a genetic component in susceptibility to 
      tuberculosis (TB) in humans. Attempts to link susceptibility to TB to human 
      leukocyte antigen (HLA) phenotype have produced conflicting data. The purpose of 
      this study was to determine whether HLA phenotype is associated with clinical TB. 
      We compared the frequencies of HLA alleles in 44 Iranian sputum smear positive 
      pulmonary TB patients with allele frequencies of 108 healthy adults. HLA typing 
      was performed by lymphocytotoxicity assay. The frequencies of HLA-B17 and -DR14 
      were higher in TB patients and the frequencies of HLA-A26 and -B27 were higher in 
      healthy controls (p value < 0.05, corrected p value [pc] >0.05). Our findings 
      suggest that these alleles are associated (either positively or negatively) with 
      pulmonary TB in an Iranian population. However, considering corrected p value, 
      our data are not conclusive and should be considered preliminary.
FAU - Mahmoudzadeh-Niknam, Hamid
AU  - Mahmoudzadeh-Niknam H
AD  - Department of Immunology, Pasteur Institute of Iran, Tehran, Iran. 
      mahmoudh@institute.pasteur.ac.ir
FAU - Khalili, Ghader
AU  - Khalili G
FAU - Fadavi, Pedram
AU  - Fadavi P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B17 antigen)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Alleles
MH  - Female
MH  - *Gene Frequency
MH  - Genes, MHC Class I/*genetics
MH  - HLA-B Antigens/*genetics
MH  - HLA-DR Antigens/*genetics
MH  - Humans
MH  - Iran
MH  - Male
MH  - Middle Aged
MH  - Tuberculosis, Pulmonary/*genetics/immunology
EDAT- 2003/01/01 04:00
MHDA- 2004/01/07 05:00
CRDT- 2003/01/01 04:00
PHST- 2003/01/01 04:00 [pubmed]
PHST- 2004/01/07 05:00 [medline]
PHST- 2003/01/01 04:00 [entrez]
AID - S0198885902007036 [pii]
AID - 10.1016/s0198-8859(02)00703-6 [doi]
PST - ppublish
SO  - Hum Immunol. 2003 Jan;64(1):124-9. doi: 10.1016/s0198-8859(02)00703-6.