PMID- 12508143
OWN - NLM
STAT- MEDLINE
DCOM- 20030130
LR  - 20171116
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 187
IP  - 1
DP  - 2003 Jan 1
TI  - Influence of plasma viremia on defects in number and immunophenotype of blood 
      dendritic cell subsets in human immunodeficiency virus 1-infected individuals.
PG  - 26-37
AB  - Dendritic cells (DCs) are postulated to be involved in transmission of human 
      immunodeficiency virus (HIV) type 1 to T cells and in stimulation of 
      HIV-1-specific cell-mediated immunity. Blood DCs have been categorized as myeloid 
      (mDC) and plasmacytoid (pDC) subsets, on the basis of differences in phenotype 
      and function. Blood DC subset numbers and expression of costimulatory molecules 
      and HIV-1 coreceptors on DCs were measured in the blood of treated and untreated 
      HIV-1-infected subjects and uninfected control subjects. Absolute numbers of mDCs 
      and pDCs were lower in HIV-1-infected subjects than in control subjects, most 
      significantly in those with active HIV-1 replication. Increased surface 
      expression of costimulatory molecules was observed on both DC subsets in subjects 
      with HIV-1 viremia. Highly active antiretroviral therapy suppression of plasma 
      viremia resulted in increases in blood DC numbers and decreases in DC 
      costimulatory molecule expression. These findings further define the impact of 
      HIV-1 replication on blood DC subsets in vivo.
FAU - Barron, Michelle A
AU  - Barron MA
AD  - Division of Infectious Diseases, Department of Medicine, University of Colorado 
      Health Sciences Center, Denver 80262, USA.
FAU - Blyveis, Naomi
AU  - Blyveis N
FAU - Palmer, Brent E
AU  - Palmer BE
FAU - MaWhinney, Samantha
AU  - MaWhinney S
FAU - Wilson, Cara C
AU  - Wilson CC
LA  - eng
GR  - AI-07447 5T32/AI/NIAID NIH HHS/United States
GR  - K08 AI-01459/AI/NIAID NIH HHS/United States
GR  - P01 AI-43664/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20021213
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Antigens, CD)
RN  - 0 (B7-2 Antigen)
RN  - 0 (CD40 Antigens)
RN  - 0 (CD86 protein, human)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (RNA, Viral)
RN  - 0 (Receptors, CCR5)
RN  - 0 (Receptors, CXCR4)
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/drug therapy/*immunology
MH  - Adult
MH  - Antigens, CD/blood
MH  - Antiretroviral Therapy, Highly Active
MH  - B7-2 Antigen
MH  - CD40 Antigens/blood
MH  - Dendritic Cells/*immunology
MH  - *HIV-1
MH  - HLA-DR Antigens/blood
MH  - Humans
MH  - Immunophenotyping
MH  - Longitudinal Studies
MH  - Membrane Glycoproteins/blood
MH  - Middle Aged
MH  - RNA, Viral/blood
MH  - Receptors, CCR5/blood
MH  - Receptors, CXCR4/blood
MH  - T-Lymphocytes/immunology
MH  - Viremia/*immunology
EDAT- 2003/01/01 04:00
MHDA- 2003/01/31 04:00
CRDT- 2003/01/01 04:00
PHST- 2002/04/17 00:00 [received]
PHST- 2002/09/10 00:00 [revised]
PHST- 2003/01/01 04:00 [pubmed]
PHST- 2003/01/31 04:00 [medline]
PHST- 2003/01/01 04:00 [entrez]
AID - JID020432 [pii]
AID - 10.1086/345957 [doi]
PST - ppublish
SO  - J Infect Dis. 2003 Jan 1;187(1):26-37. doi: 10.1086/345957. Epub 2002 Dec 13.