PMID- 12512913
OWN - NLM
STAT- MEDLINE
DCOM- 20030402
LR  - 20230525
IS  - 1357-0560 (Print)
IS  - 1357-0560 (Linking)
VI  - 19
IP  - 4
DP  - 2002
TI  - Gene-modified dendritic cells for immunotherapy against cancer.
PG  - 197-211
AB  - Dendritic cells (DCs) are described as professional antigen-presenting cells 
      because of their superior T-cell stimulatory capacity. For this reason, attention 
      is being focused on using DCs for clinical applications to treat cancer patients. 
      Although preclinical studies are promising, the majority of clinical studies with 
      DCs have not fulfilled the expectations, yet. The field of DC biology has 
      progressed rapidly over the past years, leading to several options for the 
      improvement of vaccination. Among the different parameters to investigate, this 
      review focuses on the efficiency and biological and functional consequences of 
      different gene transfer methods into different subsets of human DCs. Another 
      important consideration for DC-based vaccination is the elucidation of the role 
      of maturation and apoptosis during DC differentiation.
FAU - Lundqvist, Andreas
AU  - Lundqvist A
AD  - Cancer Center Karolinska, Immune and Gene Therapy, Department of Oncology and 
      Pathology, Radiumhemmet, Karolinska Institutet, Stockholm, Sweden.
FAU - Pisa, Pavel
AU  - Pisa P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Med Oncol
JT  - Medical oncology (Northwood, London, England)
JID - 9435512
SB  - IM
CIN - Med Oncol. 2002;19(4):195-6. PMID: 12512912
MH  - Adenoviridae/genetics
MH  - Antigen Presentation
MH  - Apoptosis
MH  - Cell Communication
MH  - Cell Differentiation
MH  - Cell Lineage
MH  - Dendritic Cells/*immunology/physiology
MH  - *Gene Transfer Techniques
MH  - Humans
MH  - *Immunotherapy
MH  - Neoplasms/*therapy
MH  - Retroviridae/genetics
MH  - T-Lymphocytes/immunology
RF  - 178
EDAT- 2003/01/07 04:00
MHDA- 2003/04/04 05:00
CRDT- 2003/01/07 04:00
PHST- 2003/01/07 04:00 [pubmed]
PHST- 2003/04/04 05:00 [medline]
PHST- 2003/01/07 04:00 [entrez]
AID - MO:19:4:197 [pii]
AID - 10.1385/MO:19:4:197 [doi]
PST - ppublish
SO  - Med Oncol. 2002;19(4):197-211. doi: 10.1385/MO:19:4:197.