PMID- 12512914
OWN - NLM
STAT- MEDLINE
DCOM- 20030402
LR  - 20181113
IS  - 1357-0560 (Print)
IS  - 1357-0560 (Linking)
VI  - 19
IP  - 4
DP  - 2002
TI  - Dendritic cell vaccines in the treatment of multiple myeloma: advances and 
      limitations.
PG  - 213-8
AB  - Dendritic cells (DCs) are antigen-presenting cells that play a key role in the 
      induction of cytotoxic T-lymphocytes. Adjuvant immunotherapy with antigen-loaded 
      DCs represents an attractive anticancer strategy for multiple myeloma (MM). 
      Autologous DCs loaded with idiotypic protein or other myeloma-associated antigen 
      have been used in several clinical trials. Preclinical and first clinical 
      experience have provided valuable insights in the mechanisms of cellular 
      immunity, but few, if any, patients with MM benefited from such vaccination. 
      Taken together, the data suggest that antitumor T-cell responses fail in MM 
      because of a deregulated cytokine network, downregulation of costimulatory 
      surface receptor expression, and changes in T-cell repertoire, enabling tumor 
      cells to escape immune effectors by preventing the antitumor immune response. We 
      discuss current clinical protocols for DC-based immunotherapy in MM and review 
      some strategies that may increase the efficacy of DC vaccines.
FAU - Buchler, Tomas
AU  - Buchler T
AD  - Department of Internal Medicine-Hematooncology, Masaryk University Hospital, 
      Jihlavska 20, 63900 Brno, Czech Republic. tbuchler@fnbrno.cz
FAU - Hajek, Roman
AU  - Hajek R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Med Oncol
JT  - Medical oncology (Northwood, London, England)
JID - 9435512
RN  - 0 (Cancer Vaccines)
SB  - IM
CIN - Med Oncol. 2002;19(4):195-6. PMID: 12512912
MH  - Cancer Vaccines/*therapeutic use
MH  - Clinical Trials as Topic
MH  - Dendritic Cells/*immunology/transplantation
MH  - Humans
MH  - Multiple Myeloma/immunology/*therapy
MH  - Vaccination
RF  - 52
EDAT- 2003/01/07 04:00
MHDA- 2003/04/04 05:00
CRDT- 2003/01/07 04:00
PHST- 2003/01/07 04:00 [pubmed]
PHST- 2003/04/04 05:00 [medline]
PHST- 2003/01/07 04:00 [entrez]
AID - MO:19:4:213 [pii]
AID - 10.1385/MO:19:4:213 [doi]
PST - ppublish
SO  - Med Oncol. 2002;19(4):213-8. doi: 10.1385/MO:19:4:213.