PMID- 12513906
OWN - NLM
STAT- MEDLINE
DCOM- 20030717
LR  - 20061115
IS  - 1079-9907 (Print)
IS  - 1079-9907 (Linking)
VI  - 22
IP  - 11
DP  - 2002 Nov
TI  - The natural alliance between type I interferon and dendritic cells and its role 
      in linking innate and adaptive immunity.
PG  - 1071-80
AB  - Dendritic cells (DCs) are the most potent antigen-presenting cells (APCs) and 
      thus play a pivotal role in induction of the immune response. Recent studies in 
      both human and mouse models have shown that type I IFN, cytokines originally 
      characterized for their antiviral activity and exerting multiple biologic 
      effects, efficiently promote the differentiation and activation of DCs. These 
      observations, together with the findings that DCs can express biologically 
      relevant levels of type I interferon (IFN) and, in particular, that high amounts 
      of these cytokines are released by specialized DC precursors (i.e., plasmacytoid 
      DCs) in response to viral infections, strongly suggest the existence of a natural 
      alliance between type I IFN and DCs, which is instrumental in ensuring an 
      efficient immune response to both infectious agents and tumors. Further recent 
      knowledge on the interactions between type I IFN and DCs emphasizes the 
      importance of these cytokines in linking innate and adaptive immunity and may 
      lead to new perspectives in their use as vaccine adjuvants as well as in 
      strategies for the development of DC-based vaccines.
FAU - Santini, Stefano M
AU  - Santini SM
AD  - Laboratory of Virology, Instituto Superiore di Sanita, Rome, Italy.
FAU - Di Pucchio, Tiziana
AU  - Di Pucchio T
FAU - Lapenta, Caterina
AU  - Lapenta C
FAU - Parlato, Stefania
AU  - Parlato S
FAU - Logozzi, Mariantonia
AU  - Logozzi M
FAU - Belardelli, Filippo
AU  - Belardelli F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - J Interferon Cytokine Res
JT  - Journal of interferon & cytokine research : the official journal of the 
      International Society for Interferon and Cytokine Research
JID - 9507088
RN  - 0 (Interferon Type I)
SB  - IM
MH  - Animals
MH  - Cell Differentiation
MH  - Dendritic Cells/cytology/*immunology
MH  - Humans
MH  - *Immunity
MH  - Interferon Type I/*immunology
RF  - 72
EDAT- 2003/01/07 04:00
MHDA- 2003/07/18 05:00
CRDT- 2003/01/07 04:00
PHST- 2003/01/07 04:00 [pubmed]
PHST- 2003/07/18 05:00 [medline]
PHST- 2003/01/07 04:00 [entrez]
AID - 10.1089/10799900260442494 [doi]
PST - ppublish
SO  - J Interferon Cytokine Res. 2002 Nov;22(11):1071-80. doi: 
      10.1089/10799900260442494.