PMID- 12514092
OWN - NLM
STAT- MEDLINE
DCOM- 20031112
LR  - 20061115
IS  - 0196-3635 (Print)
IS  - 0196-3635 (Linking)
VI  - 24
IP  - 1
DP  - 2003 Jan-Feb
TI  - Immunohistochemical detection of the retinoid X receptors alpha, beta, and gamma 
      in human prostate.
PG  - 113-9
AB  - The aim of this study was to evaluate the presence and distribution of retinoid X 
      receptors (RXRs) alpha, beta, and gamma in normal, hyperplastic (nodular, basal 
      cell, and atrophic hyperplasia), and carcinomatous human prostates in order to 
      elucidate the relationship among these receptors and the onset and development of 
      prostatic adenocarcinoma. RXRalpha and RXRgamma were immunodetected in all 
      samples of normal, nodular, and basal cell hyperplasia, as well as carcinomatous 
      prostates. In atrophic glands, the expression of both receptors was found in 
      22.5% of samples. Positive immunostaining for RXRbeta was observed in 53.3% of 
      normal prostates, 100% of samples showed basal cell hyperplasia, and were 
      negative in nodular and atrophic hyperplasia. In prostatic adenocarcinoma, only 3 
      of 25 samples (the 3 diagnosed as well-differentiated) were positive for RXRbeta. 
      Results suggest that diminished RXRbeta expression might be related to prostate 
      cancer progression and because the responsiveness to retinoic acid treatments 
      depends on the expression of different receptors, it is important to study their 
      expression before therapy.
FAU - Alfaro, Juan M
AU  - Alfaro JM
AD  - Department of Cell Biology and Genetics, University of Alcala, 28871, Alcala de 
      Henares, Spain.
FAU - Fraile, Benito
AU  - Fraile B
FAU - Lobo, Maria V T
AU  - Lobo MV
FAU - Royuela, Mar
AU  - Royuela M
FAU - Paniagua, Ricardo
AU  - Paniagua R
FAU - Arenas, Maria I
AU  - Arenas MI
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Androl
JT  - Journal of andrology
JID - 8106453
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Retinoid X Receptors)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Adenocarcinoma/metabolism
MH  - Aged
MH  - Aged, 80 and over
MH  - Blotting, Western
MH  - Case-Control Studies
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Middle Aged
MH  - Prostate/*metabolism
MH  - Prostatic Hyperplasia/metabolism
MH  - Prostatic Neoplasms/metabolism
MH  - Receptors, Retinoic Acid/*metabolism
MH  - Retinoid X Receptors
MH  - Tissue Distribution
MH  - Transcription Factors/*metabolism
EDAT- 2003/01/07 04:00
MHDA- 2003/11/13 05:00
CRDT- 2003/01/07 04:00
PHST- 2003/01/07 04:00 [pubmed]
PHST- 2003/11/13 05:00 [medline]
PHST- 2003/01/07 04:00 [entrez]
PST - ppublish
SO  - J Androl. 2003 Jan-Feb;24(1):113-9.