PMID- 12515195
OWN - NLM
STAT- MEDLINE
DCOM- 20030127
LR  - 20061115
IS  - 1003-9279 (Print)
IS  - 1003-9279 (Linking)
VI  - 12
IP  - 2
DP  - 1998 Jun
TI  - [Human herpesvirus-6 infection induces IL-10 production in monocytes].
PG  - 151-4
AB  - In this report, interleukin 10(IL-10) and other cytokines were evaluated through 
      reverse transcription-polymerase chain reaction (RT-PCR) and sandwich ELISA to 
      explore possible immune pathogenesis of human herpesvirus 6 (HHV-6) infection. 
      The results showed that IL-10 was expressed in HHV-6 infected monocytes. Kinetic 
      studies found that transcription of IL-1 beta, IL-6 and TNF-alpha mRNA decreased 
      with accumulation of IL-10 mRNA. When endogenous IL-10 induced by HHV-6 was 
      blocked using anti-human IL-10 monoclonal antibody, the production and the 
      expression of TNF-alpha, IL-1 beta and IL-6 markedly increased as compared with 
      infection by HHV-6 alone, indicating that endogenous IL-10 inhibited cytokine 
      production at the transcription level in HHV-6 infected monocytes. IL-10 has been 
      shown to suppress Th1 response and down-regulate monocyte/macrophage function. 
      The data from our studies suggest that disturbance of immune function and latent 
      infection resulting from HHV-6 infection might partially contribute to endogenous 
      IL-10 production.
FAU - Li, C
AU  - Li C
AD  - Children's Hospital, Chongqing University of Medical Sciences, Chongqing 630014.
FAU - Goodrich, J M
AU  - Goodrich JM
FAU - Yang, X
AU  - Yang X
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi
JT  - Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang 
      bingduxue zazhi = Chinese journal of experimental and clinical virology
JID - 9602873
RN  - 0 (Interleukin-6)
RN  - 0 (RNA, Messenger)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Cells, Cultured
MH  - Herpesvirus 6, Human/*immunology
MH  - Humans
MH  - Interleukin-10/*biosynthesis/genetics
MH  - Interleukin-6/biosynthesis/genetics
MH  - Monocytes/*metabolism
MH  - RNA, Messenger/biosynthesis
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Roseolovirus Infections/immunology
MH  - T-Lymphocytes/*cytology
MH  - Tumor Necrosis Factor-alpha/biosynthesis/genetics
EDAT- 2003/01/08 04:00
MHDA- 2003/01/28 04:00
CRDT- 2003/01/08 04:00
PHST- 2003/01/08 04:00 [pubmed]
PHST- 2003/01/28 04:00 [medline]
PHST- 2003/01/08 04:00 [entrez]
PST - ppublish
SO  - Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 1998 Jun;12(2):151-4.