PMID- 12517270 OWN - NLM STAT- MEDLINE DCOM- 20031219 LR - 20191025 IS - 1471-2598 (Print) IS - 1471-2598 (Linking) VI - 2 IP - 8 DP - 2002 Dec TI - Dendritic cell-based vaccines and therapies for cancer. PG - 919-28 AB - Dendritic cells (DCs) are the most potent professional antigen-presenting cells (APCs), and are capable of stimulating naive T cells and driving primary immune responses. Due to this unique property, DCs represent both vectors and targets for immunological intervention in numerous diseases and are optimal candidates for vaccination protocols in cancer. This review provides an overview of DC immunobiology and the integration of these important APCs in immunotherapies for cancer. FAU - Tatsumi, Tomohide AU - Tatsumi T AD - L1.32e Hillman Cancer Centre-UPCI Research Pavillion, L5117 Center Avenue, Pittsburgh, PA 15213, USA. FAU - Storkus, Walter J AU - Storkus WJ LA - eng GR - CA 63350/CA/NCI NIH HHS/United States GR - CA 73743/CA/NCI NIH HHS/United States PT - Journal Article PT - Research Support, U.S. Gov't, P.H.S. PT - Review PL - England TA - Expert Opin Biol Ther JT - Expert opinion on biological therapy JID - 101125414 RN - 0 (Cancer Vaccines) SB - IM MH - Animals MH - Autoimmunity/immunology MH - Cancer Vaccines/*therapeutic use MH - Clinical Trials as Topic MH - Dendritic Cells/*immunology/physiology MH - Humans MH - Immunization Schedule MH - Immunotherapy/*methods MH - Neoplasms/*immunology/*therapy MH - T-Lymphocytes/immunology RF - 123 EDAT- 2003/01/09 04:00 MHDA- 2003/12/20 05:00 CRDT- 2003/01/09 04:00 PHST- 2003/01/09 04:00 [pubmed] PHST- 2003/12/20 05:00 [medline] PHST- 2003/01/09 04:00 [entrez] AID - 10.1517/14712598.2.8.919 [doi] PST - ppublish SO - Expert Opin Biol Ther. 2002 Dec;2(8):919-28. doi: 10.1517/14712598.2.8.919.