PMID- 12519226
OWN - NLM
STAT- MEDLINE
DCOM- 20030519
LR  - 20221207
IS  - 0815-9319 (Print)
IS  - 0815-9319 (Linking)
VI  - 18
IP  - 1
DP  - 2003 Jan
TI  - Relationship between human leukocyte antigen-DRB1 and autoimmune hepatitis type I 
      in Chinese patients.
PG  - 63-7
AB  - AIM: To analyze the association of human leukocyte antigen (HLA)-DRB1 with 
      autoimmune hepatitis type I (AIH) among Chinese patients in the Shanghai area. 
      METHODS: In 32 patients and 48 healthy controls, polymerase chain reaction 
      amplified with sequence-specific primers (PCR-SSP) was performed to elucidate the 
      relevance of certain alleles or polymorphic sequences of HLA-DRB1 with autoimmune 
      hepatitis. RESULTS: The HLA-DRB1 typing by PCR-SSP showed that DR4 had a 
      significantly increased frequency among patients with AIH versus that of healthy 
      controls (46.9 vs 20.8%; relative risk = 3.35, P = 0.014). In the subtypes of 
      DR4, there was a trend of an increase in the gene frequency of DRB1*0405 in 
      patients with AIH versus that of healthy controls (21.9 vs 6.3%, P = 0.04, but 
      corrected P (Pc) = 0.08). In addition, our analysis indicated a significant 
      increase in the alleles frequency encoding Leu-Leu-Glu-Gln-Lys-Arg (LLEQRR) from 
      the third hyperpolymorphic region (HVR3) of DR4 in the patients with AIH (86.7% 
      of DR4 positive patients vs 40.0% in DR4 positive controls, P = 0.016, Pc = 
      0.028, relative risk (RR) = 9.75). CONCLUSION: Type I AIH among Chinese patients 
      is associated with HLA-DR4. There is a relevance of type I AIH and LLEQRR 
      sequence within the third hyperpolymorphic region of the DRB1 allele.
CI  - Copyright 2003 Blackwell Publishing Asia Pty Ltd
FAU - Qiu, De-Kai
AU  - Qiu DK
AD  - Shanghai Renji Hospital, Shanghai Institute of Digestive Disease, Shanghai Second 
      Medical University, Shanghai, China. dekaiqu@sh163.net
FAU - Ma, Xiong
AU  - Ma X
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - J Gastroenterol Hepatol
JT  - Journal of gastroenterology and hepatology
JID - 8607909
RN  - 0 (Epitopes)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DR4 Antigen)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Amino Acid Motifs/genetics
MH  - *Asian People
MH  - Epitopes/genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease/genetics
MH  - HLA-DR Antigens/*analysis/genetics
MH  - HLA-DR4 Antigen/genetics
MH  - HLA-DRB1 Chains
MH  - Hepatitis, Autoimmune/*ethnology/genetics/*immunology
MH  - Humans
MH  - Middle Aged
MH  - Reference Values
EDAT- 2003/01/10 04:00
MHDA- 2003/05/20 05:00
CRDT- 2003/01/10 04:00
PHST- 2003/01/10 04:00 [pubmed]
PHST- 2003/05/20 05:00 [medline]
PHST- 2003/01/10 04:00 [entrez]
AID - 2918 [pii]
AID - 10.1046/j.1440-1746.2003.02918.x [doi]
PST - ppublish
SO  - J Gastroenterol Hepatol. 2003 Jan;18(1):63-7. doi: 
      10.1046/j.1440-1746.2003.02918.x.