PMID- 12520171
OWN - NLM
STAT- MEDLINE
DCOM- 20030625
LR  - 20211203
IS  - 0918-6158 (Print)
IS  - 0918-6158 (Linking)
VI  - 26
IP  - 1
DP  - 2003 Jan
TI  - Induction of triglyceride accumulation in the liver of rats by perfluorinated 
      fatty acids with different carbon chain lengths: comparison with induction of 
      peroxisomal beta-oxidation.
PG  - 47-51
AB  - The potency to accumulate triglyceride (TG) was compared between perfluorinated 
      fatty acids (PFCAs) with different carbon chain lengths in the liver of male and 
      female rats and induction of peroxisomal beta-oxidation. In male rats, either 
      perfluoroheptanoic acid (C7) or perfluorooctanoic acid (C8) had no effect, 
      although perfluorononanonic acid (C9) and perfluorodecanoic acid (C10) markedly 
      accumulated TG. In female rats, C7, C8, and C9 did not cause TG accumulation, 
      whereas C10 caused TG accumulation at the same level as in male rats. TG 
      accumulation induced by C9 was regulated by the level of testosterone in male 
      rats. In contrast with TG accumulation, peroxisomal beta-oxidation was induced by 
      C8, C9, and C10 in male rats and by C9 and C10 in female rats. Only a slight 
      difference was observed in the induction by C9 between male and female rats. The 
      induction of TG accumulation by these PFCAs occurred in a dose-dependent manner 
      and significantly correlated with hepatic concentrations of PFCA regardless of 
      their carbon chain length, as was observed with induction of peroxisomal 
      beta-oxidation. There is, however, a striking difference in the hepatic 
      concentration of PFCA required to cause induction of TG accumulation and that of 
      peroxisomal beta-oxidation. The concentration of PFCA required to induce TG 
      accumulation is much higher than that to induce peroxisomal beta-oxidation. These 
      results strongly suggest that TG accumulation induced by PFCAs, as well as the 
      induction of peroxisomal beta-oxidation, is dependent only on the number of PFCA 
      molecules in hepatocytes, but is not due to the difference in their chemical 
      structures, and that there is a marked difference in the PFCA threshold to cause 
      distinct biological effects.
FAU - Kudo, Naomi
AU  - Kudo N
AD  - Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, 
      Saitama 350-0295, Japan. naokudo@josai.ac.jp
FAU - Kawashima, Yoichi
AU  - Kawashima Y
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Biol Pharm Bull
JT  - Biological & pharmaceutical bulletin
JID - 9311984
RN  - 0 (Fatty Acids)
RN  - 0 (Fluorocarbons)
RN  - 0 (Heptanoic Acids)
RN  - 0 (Hydrocarbons, Fluorinated)
RN  - 0 (Triglycerides)
RN  - 1763-10-6 (Palmitoyl Coenzyme A)
RN  - 375-85-9 (perfluoro-n-heptanoic acid)
SB  - IM
MH  - Animals
MH  - Dose-Response Relationship, Drug
MH  - Fatty Acids/chemistry/pharmacology
MH  - Female
MH  - Fluorocarbons
MH  - Heptanoic Acids/chemistry/*pharmacology
MH  - Hydrocarbons, Fluorinated/*pharmacology
MH  - Liver/*drug effects/metabolism
MH  - Male
MH  - Palmitoyl Coenzyme A/*metabolism
MH  - Peroxisomes/*drug effects/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Triglycerides/biosynthesis/*metabolism
EDAT- 2003/01/10 04:00
MHDA- 2003/06/26 05:00
CRDT- 2003/01/10 04:00
PHST- 2003/01/10 04:00 [pubmed]
PHST- 2003/06/26 05:00 [medline]
PHST- 2003/01/10 04:00 [entrez]
AID - 10.1248/bpb.26.47 [doi]
PST - ppublish
SO  - Biol Pharm Bull. 2003 Jan;26(1):47-51. doi: 10.1248/bpb.26.47.