PMID- 12520544
OWN - NLM
STAT- MEDLINE
DCOM- 20030725
LR  - 20210924
IS  - 0730-2312 (Print)
IS  - 0730-2312 (Linking)
VI  - 88
IP  - 2
DP  - 2003 Feb 1
TI  - HGF/SF-met signaling in the control of branching morphogenesis and invasion.
PG  - 408-17
AB  - Hepatocyte growth factor/Scatter factor (HGF/SF) is a multifunctional growth 
      factor which can induce diverse biological events. In vitro, these include 
      scattering, invasion, proliferation and branching morphogenesis. In vivo, HGF/SF 
      is responsible for many processes during embryonic development and a variety of 
      activities in adults, and many of these normal activities have been implicated in 
      its role in tumorgenesis and metastasis. The c-Met receptor tyrosine kinase is 
      the only known receptor for HGF/SF and mediates all HGF/SF induced biological 
      activities. Upon HGF/SF stimulation, the c-Met receptor is 
      tyrosine-phosphorylated which is followed by the recruitment of a group of 
      signaling molecules and/or adaptor proteins to its cytoplasmic domain and its 
      multiple docking sites. This action leads to the activation of several different 
      signaling cascades that form a complete network of intra and extracellular 
      responses. Different combinations of signaling pathways and signaling molecules 
      and/or differences in magnitude of responses contribute to these diverse series 
      of HGF/SF-Met induced activities and most certainly are influenced by cell type 
      as well as different cellular environments. In this review, we focus on 
      HGF/SF-induced branching morphogenesis and invasion, and bring together recent 
      new findings which provide insight into how HGF/SF, via c-Met induces this 
      response.
CI  - Copyright 2002 Wiley-Liss, Inc.
FAU - Zhang, Yu-Wen
AU  - Zhang YW
AD  - Laboratory of Molecular Oncology, Van Andel Research Institute, 333 Bostwick Ave. 
      NE, Grand Rapids, Michigan 49503, USA.
FAU - Vande Woude, George F
AU  - Vande Woude GF
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Cell Biochem
JT  - Journal of cellular biochemistry
JID - 8205768
RN  - 67256-21-7 (Hepatocyte Growth Factor)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
SB  - IM
MH  - Animals
MH  - Extracellular Matrix/metabolism
MH  - Hepatocyte Growth Factor/*metabolism
MH  - Humans
MH  - *Morphogenesis
MH  - *Neoplasm Invasiveness
MH  - Neoplasms/pathology
MH  - Protein-Tyrosine Kinases/metabolism
MH  - Proto-Oncogene Proteins c-met/metabolism
MH  - Signal Transduction/*physiology
RF  - 55
EDAT- 2003/01/10 04:00
MHDA- 2003/07/26 05:00
CRDT- 2003/01/10 04:00
PHST- 2003/01/10 04:00 [pubmed]
PHST- 2003/07/26 05:00 [medline]
PHST- 2003/01/10 04:00 [entrez]
AID - 10.1002/jcb.10358 [doi]
PST - ppublish
SO  - J Cell Biochem. 2003 Feb 1;88(2):408-17. doi: 10.1002/jcb.10358.