PMID- 12524092
OWN - NLM
STAT- MEDLINE
DCOM- 20030130
LR  - 20190707
IS  - 0015-0282 (Print)
IS  - 0015-0282 (Linking)
VI  - 79
IP  - 1
DP  - 2003 Jan
TI  - Sperm chromosomal abnormalities are linked to sperm morphologic deformities.
PG  - 212-5
AB  - OBJECTIVE: To describe the association between specific sperm morphologic 
      abnormalities and sperm chromosomal abnormalities on multicolor interphase 
      fluorescence in situ hybridization (FISH). DESIGN: Case report. Reproductive 
      medicine unit in a tertiary referral center. PATIENT(S): Three infertile men with 
      severe oligoasthenospermia and total teratozoospermia who were referred for IVF 
      treatment. MAIN OUTCOME MEASURE(S): Incidence of spermatozoal chromosomal 
      aneuploidy for chromosome 18 and the sex chromosomes by using FISH. RESULT(S): 
      Morphologic assessment of sperm revealed a high incidence of double heads, 
      multinucleated sperm heads, and multiple tails. Hormone profiles and karyotyping 
      of peripheral lymphocytes were normal in the three men. The proportion of sperm 
      with disomy, trisomy and tetrasomy for chromosome 18, and the sex chromosomes in 
      each patient was 100%, 76%, and 82.5%, respectively. CONCLUSION(S): Specific 
      morphologic abnormalities of sperm may be associated with higher incidence of 
      chromosomal abnormalities. Resolving infertility by offering patients in vitro 
      fertilization/intracytoplasmic sperm injection must be approached with caution 
      because of the significant risk for embryonic aneuploidy and chromosomal 
      abnormalities in any subsequent offspring.
FAU - Lewis-Jones, Iwan
AU  - Lewis-Jones I
AD  - Department of Obstetrics and Gynaecology, The University of Liverpool, Liverpool, 
      United Kingdom.
FAU - Aziz, Nabil
AU  - Aziz N
FAU - Seshadri, Srividya
AU  - Seshadri S
FAU - Douglas, Angela
AU  - Douglas A
FAU - Howard, Peter
AU  - Howard P
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
SB  - IM
MH  - Adult
MH  - Cell Nucleus
MH  - *Chromosome Aberrations
MH  - Chromosomes, Human, Pair 18
MH  - Chromosomes, Human, X
MH  - Chromosomes, Human, Y
MH  - Female
MH  - Fertilization in Vitro
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Infertility, Male/*genetics
MH  - Male
MH  - Sex Chromosome Aberrations
MH  - Sperm Head
MH  - Sperm Tail
MH  - Spermatozoa/*abnormalities/*ultrastructure
EDAT- 2003/01/14 04:00
MHDA- 2003/01/31 04:00
CRDT- 2003/01/14 04:00
PHST- 2003/01/14 04:00 [pubmed]
PHST- 2003/01/31 04:00 [medline]
PHST- 2003/01/14 04:00 [entrez]
AID - S0015028202044114 [pii]
AID - 10.1016/s0015-0282(02)04411-4 [doi]
PST - ppublish
SO  - Fertil Steril. 2003 Jan;79(1):212-5. doi: 10.1016/s0015-0282(02)04411-4.