PMID- 12524635
OWN - NLM
STAT- MEDLINE
DCOM- 20030422
LR  - 20071114
IS  - 0010-440X (Print)
IS  - 0010-440X (Linking)
VI  - 44
IP  - 1
DP  - 2003 Jan-Feb
TI  - Functioning and interpersonal relationships as predictors of response in 
      treatment-resistant depression.
PG  - 44-50
AB  - The purpose of this study was to examine whether occupational functioning or the 
      quality of interpersonal relationships is predictive of clinical response to a 
      6-week open trial of nortriptyline (NT) in patients with treatment-resistant 
      depression (TRD). Ninety-two subjects with TRD were treated openly with NT for 6 
      weeks. The longitudinal interval follow-up evaluation (LIFE) scale was 
      administered at baseline. A logistic regression was performed using occupational 
      functioning and interpersonal relationships (over the past month and over the 
      past 5 years) as predictors of treatment response. Unpaired t tests were 
      performed to examine mean composite LIFE score values between responders and 
      nonresponders. The composite scores that were statistically significant were used 
      as single predictors of treatment status in separate logistic regression 
      equations. Better occupational function over the past 5 years predicted better 
      response to treatment with NT in patients with TRD. Beyond a history of 
      nonresponse to antidepressants, long-term occupational function may be a 
      predictor of outcome in the treatment of TRD.
CI  - Copyright 2003, Elsevier Science (USA). All rights reserved.
FAU - Papakostas, George I
AU  - Papakostas GI
AD  - Depression Clinical and Research Program, Massachusetts General Hospital, Boston, 
      MA, USA.
FAU - Petersen, Timothy
AU  - Petersen T
FAU - Mischoulon, David
AU  - Mischoulon D
FAU - Hughes, Megan E
AU  - Hughes ME
FAU - Spector, Andrew R
AU  - Spector AR
FAU - Alpert, Jonathan E
AU  - Alpert JE
FAU - Fava, Maurizio
AU  - Fava M
FAU - Nierenberg, Andrew A
AU  - Nierenberg AA
LA  - eng
GR  - R29 MH46952/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Compr Psychiatry
JT  - Comprehensive psychiatry
JID - 0372612
RN  - 0 (Antidepressive Agents)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Antidepressive Agents/*therapeutic use
MH  - Depressive Disorder, Major/*drug therapy
MH  - Drug Resistance
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - *Interpersonal Relations
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Retrospective Studies
EDAT- 2003/01/14 04:00
MHDA- 2003/04/23 05:00
CRDT- 2003/01/14 04:00
PHST- 2003/01/14 04:00 [pubmed]
PHST- 2003/04/23 05:00 [medline]
PHST- 2003/01/14 04:00 [entrez]
AID - S0010440X03000324 [pii]
AID - 10.1053/comp.2003.50012 [doi]
PST - ppublish
SO  - Compr Psychiatry. 2003 Jan-Feb;44(1):44-50. doi: 10.1053/comp.2003.50012.