PMID- 12524668
OWN - NLM
STAT- MEDLINE
DCOM- 20030131
LR  - 20131121
IS  - 0026-0495 (Print)
IS  - 0026-0495 (Linking)
VI  - 52
IP  - 1
DP  - 2003 Jan
TI  - Level of glycogen stores and amount of ingested glucose regulate net carbohydrate 
      storage by different mechanisms.
PG  - 94-101
AB  - The respective effects of the level of glycogen stores and the size of the 
      glucose load on the pathways of carbohydrate (CHO) metabolism were compared over 
      the 5-hour period following glucose ingestion in normal human subjects. For this 
      purpose, labeling of the oral glucose load with [3-(3)H]- and [U(14)C] glucose 
      was combined with indirect calorimetry. In group I, 75 g glucose was given to 
      subjects who had either been "fed" with intravenous (IV) glucose or fasted for 
      13, 24, or 36 hours, or 4 days. In fed versus 4-day-fasted subjects, net CHO 
      storage averaged approximately 15 versus 63 g/5 h (P <.001). About 83% of the 
      increase in fasted subjects was due to suppression of glycogen breakdown, with 
      only minimal stimulation of glycogen synthesis from oral glucose. Over the whole 
      range of nutritional conditions tested, a strong positive correlation existed 
      between basal CHO oxidation and glycogen breakdown occurring during the oral 
      glucose tolerance test (OGTT), suggesting that the initial degree of repletion of 
      hepatic glycogen stores is a major determinant of postprandial glycogen turnover. 
      In group II, OGTTs with 33 and 100 g glucose were compared in 13-hour-fasted 
      subjects. Net storage rose from approximately -6 to approximately 37 g/5 h (P 
      <.001) solely because of an increase in glycogen synthesis with no inhibition of 
      glycogen turnover. Overall, these results show that the initial dietary state and 
      the size of the glucose load modulate postprandial net CHO accumulation by 
      different mechanisms.
CI  - Copyright 2003, Elsevier Science (USA). All rights reserved.
FAU - Fery, F
AU  - Fery F
AD  - Laboratory of Experimental Medicine, Hopital Erasme, University of Brussels, 
      Brussels, Belgium.
FAU - Plat, L
AU  - Plat L
FAU - Balasse, E O
AU  - Balasse EO
LA  - eng
PT  - Clinical Trial
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Metabolism
JT  - Metabolism: clinical and experimental
JID - 0375267
RN  - 0 (Blood Glucose)
RN  - 9005-79-2 (Glycogen)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Adult
MH  - Blood Glucose/metabolism
MH  - Calorimetry, Indirect
MH  - *Carbohydrate Metabolism
MH  - Female
MH  - Glucose/*pharmacology
MH  - Glucose Tolerance Test
MH  - Glycogen/biosynthesis/*metabolism
MH  - Glycolysis/physiology
MH  - Humans
MH  - Kinetics
MH  - Male
MH  - Nutritional Status/physiology
MH  - Oxidation-Reduction
MH  - Postprandial Period/physiology
EDAT- 2003/01/14 04:00
MHDA- 2003/02/01 04:00
CRDT- 2003/01/14 04:00
PHST- 2003/01/14 04:00 [pubmed]
PHST- 2003/02/01 04:00 [medline]
PHST- 2003/01/14 04:00 [entrez]
AID - S0026049503500178 [pii]
AID - 10.1053/meta.2003.50015 [doi]
PST - ppublish
SO  - Metabolism. 2003 Jan;52(1):94-101. doi: 10.1053/meta.2003.50015.