PMID- 12526905
OWN - NLM
STAT- MEDLINE
DCOM- 20030303
LR  - 20190822
IS  - 0048-9697 (Print)
IS  - 0048-9697 (Linking)
VI  - 302
IP  - 1-3
DP  - 2003 Jan 20
TI  - Partitioning of persistent organic pollutants in grey seal (Halichoerus grypus) 
      mother-pup pairs.
PG  - 145-55
AB  - Phocid seals have lipid rich milk, which is known to serve as a transfer medium 
      through which persistent organic pollutants (POPs) move from mother to offspring 
      during lactation. However, knowledge on this generational transfer of different 
      POPs and the partitioning of these compounds in maternal and offspring tissues 
      over the course of the lactation are limited. In this study we examined the 
      qualitative and quantitative partitioning of a range of chlorinated POPs in 
      maternal blubber, blood and milk as well as in pup blubber, collected early in 
      the lactation period and late in the lactation period. In the lactating female, 
      the high-chlorinated and hydrophobic compounds were passed less efficiently into 
      the milk than the low-chlorinated compounds and more water-soluble compounds. 
      Significantly, lower maternal blood concentrations than in maternal blubber 
      biopsies suggest a stratification of POP concentrations in the blubber column of 
      lactating female and lower concentrations in the metabolic active inner layers. 
      Over the course of lactation, there was a significant increase in maternal blood 
      and milk concentrations of POPs as opposed to no change in maternal blubber 
      biopsy concentrations. This was most apparent for the hydrophobic and 
      high-chlorinated compounds. The most likely explanation for this is that the 
      metabolic active inner blubber layer, from which the milk lipids are derived 
      from, is in steady state with the circulatory system, while the outer layers are 
      more static and only slowly respond to changes in concentrations elsewhere in the 
      body. The concentrations of the high-chlorinated and hydrophobic compounds were 
      substantially lower in pup blubber than in maternal blubber. This probably 
      relates the combined effect of these compounds stratification in maternal blubber 
      and their slow transfer into the milk. The present study shows that the more 
      hydrophobic and high-chlorinated compounds come to steady state less quickly in 
      the different tissues than the more water-soluble and low-chlorinated compounds 
      in the lactating female and her offspring. This has implications for which 
      matrices to choose when sampling for assessing the toxicological risk of POPs in 
      seals.
CI  - Copyright 2002 Elsevier Science B.V.
FAU - Sormo, E G
AU  - Sormo EG
AD  - Department of Biology, Norwegian University of Science and Technology, N-7491 
      Trondheim, Norway. eugen.sormo@nt.ntnu.no
FAU - Skaare, J U
AU  - Skaare JU
FAU - Lydersen, C
AU  - Lydersen C
FAU - Kovacs, K M
AU  - Kovacs KM
FAU - Hammill, M O
AU  - Hammill MO
FAU - Jenssen, B M
AU  - Jenssen BM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Insecticides)
SB  - IM
MH  - Adipose Tissue/*chemistry
MH  - Animals
MH  - Animals, Newborn
MH  - Biopsy
MH  - Female
MH  - *Hydrocarbons, Chlorinated
MH  - Insecticides/analysis/*pharmacokinetics
MH  - *Lactation
MH  - Risk Assessment
MH  - *Seals, Earless
MH  - Tissue Distribution
EDAT- 2003/01/16 04:00
MHDA- 2003/03/04 04:00
CRDT- 2003/01/16 04:00
PHST- 2003/01/16 04:00 [pubmed]
PHST- 2003/03/04 04:00 [medline]
PHST- 2003/01/16 04:00 [entrez]
AID - S0048-9697(02)00300-5 [pii]
AID - 10.1016/s0048-9697(02)00300-5 [doi]
PST - ppublish
SO  - Sci Total Environ. 2003 Jan 20;302(1-3):145-55. doi: 
      10.1016/s0048-9697(02)00300-5.