PMID- 12526952
OWN - NLM
STAT- MEDLINE
DCOM- 20030325
LR  - 20111117
IS  - 0002-9270 (Print)
IS  - 0002-9270 (Linking)
VI  - 98
IP  - 1
DP  - 2003 Jan
TI  - Influence of TNF gene polymorphism and HLA-DRB1 haplotype in Japanese patients 
      with chronic liver disease caused by HCV.
PG  - 160-6
AB  - OBJECTIVE: To clarify the host genomic role in chronic liver disease associated 
      with hepatitis C virus (HCV), we investigated the relationship between the 
      severity of hepatitis and the polymorphisms of the tumor necrosis factor (TNF) 
      gene or the human leukocyte antigen (HLA)-DRB1 haplotypes. METHODS: We analyzed 
      40 healthy subjects, 50 patients with chronic inactive hepatitis caused by HCV 
      with mean serum ALT concentrations under 40 IU/ml (group A), and 50 patients with 
      chronic active liver disease caused by HCV and mean ALT concentrations over 50 
      IU/ml (group B). RESULTS: There were no significant differences in the 
      frequencies of TNF promoter gene variants at positions -238 and -308 between the 
      groups. Regarding polymorphisms at the TNF-beta NcoI site, the frequency of B1B1 
      homozygotes in group A was significantly increased, compared with the healthy 
      subjects and those in group B (controls 7.5%, group A 34%, group B 10%). 
      Regarding the analysis of HLA-DRB1, DRB1*0901 was significantly more frequent in 
      group A than in group B (group A 19%, group B 5%). TNF B1B1 homozygotes were 
      associated with HLA-DRB1*0901 and *1302, and negatively associated with 
      DRB1*0405. Combination analysis revealed that HCV was inactive in the majority of 
      patients who were both DRB1*0901 and B1B1 homozygotes. CONCLUSION: Our data 
      suggest that TNF gene polymorphisms and HLA-DRB1 haplotype may influence the 
      activity of HCV in chronic liver disease.
FAU - Tokushige, Katsutoshi
AU  - Tokushige K
AD  - Division of Medicine, Institute of Gastroenterology, Tokyo Women's Medical 
      University, Tokyo, Japan.
FAU - Tsuchiya, Noriko
AU  - Tsuchiya N
FAU - Hasegawa, Kiyoshi
AU  - Hasegawa K
FAU - Hashimoto, Etsuko
AU  - Hashimoto E
FAU - Yamauchi, Katsumi
AU  - Yamauchi K
FAU - Komatsu, Tatsuzi
AU  - Komatsu T
FAU - Hayashi, Naoaki
AU  - Hayashi N
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Gastroenterol
JT  - The American journal of gastroenterology
JID - 0421030
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Female
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - *Haplotypes
MH  - Hepatitis C, Chronic/*genetics
MH  - Humans
MH  - Japan
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Tumor Necrosis Factor-alpha/*genetics
EDAT- 2003/01/16 04:00
MHDA- 2003/03/26 05:00
CRDT- 2003/01/16 04:00
PHST- 2003/01/16 04:00 [pubmed]
PHST- 2003/03/26 05:00 [medline]
PHST- 2003/01/16 04:00 [entrez]
AID - S0002927002058458 [pii]
AID - 10.1111/j.1572-0241.2003.07177.x [doi]
PST - ppublish
SO  - Am J Gastroenterol. 2003 Jan;98(1):160-6. doi: 10.1111/j.1572-0241.2003.07177.x.