PMID- 12527222
OWN - NLM
STAT- MEDLINE
DCOM- 20030731
LR  - 20191210
IS  - 0165-2478 (Print)
IS  - 0165-2478 (Linking)
VI  - 85
IP  - 2
DP  - 2003 Jan 22
TI  - Dendritic cells as a tool to combat infectious diseases.
PG  - 153-7
AB  - Dendritic cells (DCs) form a network of potent antigen-presenting cells that 
      initiate and amplify immune responses. The detection and capture of 
      microorganisms by DCs trigger stimulus-specific maturation programs that enable 
      DCs to convey pathogen-associated signals to the adaptive branch of the immune 
      system. The appropriate activation of DCs is critical for their ability to direct 
      the development of either a Th1 or a Th2 response, thereby determining the 
      outcome of microbial infections. Advances in the understanding of DC interactions 
      with microbes provide new concepts for immune interventions. In different models 
      of infectious disease, it has been demonstrated that DCs can serve as vaccine 
      carriers, mediating protection against various types of pathogens. The studies of 
      the requirements of ex vivo manipulations of DCs may lead to the design of 
      vaccines that induce protective immunity to infections by appropriate targeting 
      of DCs in vivo.
FAU - Moll, Heidrun
AU  - Moll H
AD  - Institute for Molecular Biology of Infectious Diseases, University of Wurzburg, 
      Rontgenring 11, 97070 Wurzburg, Germany. heidrun.moll@mail.uni-wuerzberg.de
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - Immunol Lett
JT  - Immunology letters
JID - 7910006
RN  - 0 (Vaccines)
SB  - IM
MH  - Animals
MH  - Antigen Presentation/*immunology
MH  - Cell Differentiation
MH  - Dendritic Cells/cytology/*immunology
MH  - Humans
MH  - Immunotherapy, Adoptive/methods
MH  - Infections/*immunology
MH  - Leishmaniasis, Cutaneous/immunology/prevention & control
MH  - Models, Animal
MH  - Vaccines/immunology
RF  - 28
EDAT- 2003/01/16 04:00
MHDA- 2003/08/02 05:00
CRDT- 2003/01/16 04:00
PHST- 2003/01/16 04:00 [pubmed]
PHST- 2003/08/02 05:00 [medline]
PHST- 2003/01/16 04:00 [entrez]
AID - S0165247802002225 [pii]
AID - 10.1016/s0165-2478(02)00222-5 [doi]
PST - ppublish
SO  - Immunol Lett. 2003 Jan 22;85(2):153-7. doi: 10.1016/s0165-2478(02)00222-5.