PMID- 12528020
OWN - NLM
STAT- MEDLINE
DCOM- 20030605
LR  - 20131121
IS  - 0342-4642 (Print)
IS  - 0342-4642 (Linking)
VI  - 29
IP  - 1
DP  - 2003 Jan
TI  - End-expiratory lung impedance change enables bedside monitoring of end-expiratory 
      lung volume change.
PG  - 37-43
AB  - OBJECTIVE: The aim of the study was to investigate the effect of lung volume 
      changes on end-expiratory lung impedance change (ELIC) in mechanically ventilated 
      patients, since we hypothesized that ELIC may be a suitable parameter to monitor 
      lung volume change at the bedside. DESIGN: Clinical trial on patients requiring 
      mechanical ventilation. SETTINGS: Intensive care units of a university hospital. 
      PATIENTS: Ten mechanically ventilated patients were included in the study. 
      INTERVENTION: Patients were ventilated in volume-controlled mode with constant 
      flow and respiratory rate. In order to induce changes in the end-expiratory lung 
      volume (EELV), PEEP levels were increased from 0 mbar to 5 mbar, 10 mbar, and 15 
      mbar. At each PEEP level EELV was measured by an open-circuit nitrogen washout 
      manoeuvre and ELIC was measured simultaneously using Electrical Impedance 
      Tomography (EIT) with sixteen electrodes placed on the circumference of the 
      thorax and connected with an EIT device. Cross-sectional electro-tomographic 
      measurements of the thorax were performed at each PEEP level, and a modified 
      Sheffield back-projection was used to reconstruct images of the lung impedance. 
      ELIC was calculated as the average of the end-expiratory lung impedance change. 
      RESULTS. Increasing PEEP stepwise from 0 mbar to 15 mbar resulted in an linear 
      increase of EELV and ELIC according to the equation: y =0.98 x -0.68, r(2)=0.95. 
      CONCLUSION: EIT is a simple bedside technique which enables monitor lung volume 
      changes during ventilatory manoeuvres such as PEEP changes.
FAU - Hinz, J
AU  - Hinz J
AD  - Department of Anaesthesiology, Emergency and Intensive Care Medicine, University 
      of Gottingen, Robert-Koch-Str 40, 37075 Gottingen, Germany. mail@josehinz.de
FAU - Hahn, G
AU  - Hahn G
FAU - Neumann, P
AU  - Neumann P
FAU - Sydow, M
AU  - Sydow M
FAU - Mohrenweiser, P
AU  - Mohrenweiser P
FAU - Hellige, G
AU  - Hellige G
FAU - Burchardi, H
AU  - Burchardi H
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20021120
PL  - United States
TA  - Intensive Care Med
JT  - Intensive care medicine
JID - 7704851
RN  - N762921K75 (Nitrogen)
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Electric Impedance
MH  - Humans
MH  - Least-Squares Analysis
MH  - Lung Volume Measurements/*methods
MH  - Middle Aged
MH  - Nitrogen/analysis
MH  - *Point-of-Care Systems
MH  - *Positive-Pressure Respiration
MH  - Respiratory Mechanics
MH  - Statistics, Nonparametric
MH  - Tomography/*methods
EDAT- 2003/01/16 04:00
MHDA- 2003/06/06 05:00
CRDT- 2003/01/16 04:00
PHST- 2001/12/20 00:00 [received]
PHST- 2002/10/11 00:00 [accepted]
PHST- 2003/01/16 04:00 [pubmed]
PHST- 2003/06/06 05:00 [medline]
PHST- 2003/01/16 04:00 [entrez]
AID - 10.1007/s00134-002-1555-4 [doi]
PST - ppublish
SO  - Intensive Care Med. 2003 Jan;29(1):37-43. doi: 10.1007/s00134-002-1555-4. Epub 
      2002 Nov 20.