PMID- 12531230
OWN - NLM
STAT- MEDLINE
DCOM- 20030416
LR  - 20190826
IS  - 0145-2126 (Print)
IS  - 0145-2126 (Linking)
VI  - 27
IP  - 4
DP  - 2003 Apr
TI  - Ph-negative acute lymphocytic leukemia occurring after interferon therapy for 
      Ph-positive chronic myelocytic leukemia.
PG  - 367-9
AB  - We report a unique case of chronic myelocytic leukemia (CML) with the 
      Philadelphia (Ph) chromosome. The patient obtained cytogenetic complete remission 
      (CR) after treatment with interferon (IFN). When he transformed to acute 
      lymphocytic leukemia (ALL), cytogenetic analysis showed that the karyotype was 
      normal and fluorescence in situ hybridization (FISH) indicated that blast cells 
      were Ph-negative. Immunophenotyping showed that the cells were CD34-positive and 
      CD38-negative. Blast cells in his final stage were BCR/ABL rearrangement negative 
      by reverse transcription polymerase chain reaction (RT-PCR).
FAU - Zhang, Xinwei
AU  - Zhang X
AD  - Department of Clinical Hematology, Institute of Hematology, Blood Diseases 
      Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, 
      Tianjin, PR China.
FAU - Ji, Linxiang
AU  - Ji L
FAU - Liu, Shihe
AU  - Liu S
FAU - Wang, Jianxiang
AU  - Wang J
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Leuk Res
JT  - Leukemia research
JID - 7706787
RN  - 0 (Interferon-alpha)
SB  - IM
MH  - Cell Transformation, Neoplastic/pathology
MH  - Clone Cells/pathology
MH  - Cytogenetic Analysis
MH  - Fatal Outcome
MH  - Humans
MH  - Immunophenotyping
MH  - Interferon-alpha/*administration & dosage/adverse effects
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*drug therapy/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasms, Second Primary/*chemically induced/*genetics/pathology
MH  - *Philadelphia Chromosome
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*chemically 
      induced/*genetics/pathology
EDAT- 2003/01/18 04:00
MHDA- 2003/04/17 05:00
CRDT- 2003/01/18 04:00
PHST- 2003/01/18 04:00 [pubmed]
PHST- 2003/04/17 05:00 [medline]
PHST- 2003/01/18 04:00 [entrez]
AID - S0145212602001753 [pii]
AID - 10.1016/s0145-2126(02)00175-3 [doi]
PST - ppublish
SO  - Leuk Res. 2003 Apr;27(4):367-9. doi: 10.1016/s0145-2126(02)00175-3.