PMID- 12531783
OWN - NLM
STAT- MEDLINE
DCOM- 20030520
LR  - 20200930
IS  - 0363-6119 (Print)
IS  - 0363-6119 (Linking)
VI  - 284
IP  - 5
DP  - 2003 May
TI  - Relative contribution of the TNF-alpha receptors to murine intimal hyperplasia.
PG  - R1213-8
AB  - Tumor necrosis factor-alpha (TNF-alpha) is an important mediator in the 
      inflammatory response to vascular injury. The present study sought to determine 
      the relative contribution of each TNF-alpha receptor subtype (p55 and p75) to 
      intimal hyperplasia (IH) and characterize the mechanisms of transcriptional 
      regulation after vascular injury. A murine model of wire carotid arterial injury 
      was employed to induce IH in wild-type (WT), p55-deficient (p55-/-), and 
      p75-deficient (p75-/-) mice. Compared with injured WT and p75-/- animals, p55-/- 
      mice demonstrated a twofold reduction in IH. Additionally, p55-/- mice 
      demonstrated a decrease in expression of nuclear factor-kappaB mRNA and protein. 
      These observations suggest an important role for the p55 receptor in IH after 
      mechanical endoluminal injury. Suppression of the transcriptional activator 
      nuclear factor-kappaB may provide a mechanism by which p55-mediated IH is 
      attenuated.
FAU - Zimmerman, Michael A
AU  - Zimmerman MA
AD  - Divisions of Cardiothoracic Surgery and Infectious Disease, University of 
      Colorado Health Sciences Center, Denver, Colorado 80262, USA.
FAU - Reznikov, Leonid L
AU  - Reznikov LL
FAU - Sorensen, Amy C
AU  - Sorensen AC
FAU - Selzman, Craig H
AU  - Selzman CH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20030116
PL  - United States
TA  - Am J Physiol Regul Integr Comp Physiol
JT  - American journal of physiology. Regulatory, integrative and comparative 
      physiology
JID - 100901230
RN  - 0 (Antigens, CD)
RN  - 0 (NF-kappa B)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type I)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type II)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Antigens, CD/genetics/*metabolism
MH  - Carotid Artery Injuries/metabolism/pathology
MH  - Gene Expression Regulation
MH  - Hyperplasia/*metabolism/pathology
MH  - Male
MH  - Mice
MH  - Mice, Knockout
MH  - NF-kappa B/metabolism
MH  - Receptors, Tumor Necrosis Factor/genetics/*metabolism
MH  - Receptors, Tumor Necrosis Factor, Type I
MH  - Receptors, Tumor Necrosis Factor, Type II
MH  - Tumor Necrosis Factor-alpha/metabolism
MH  - Tunica Intima/injuries/*metabolism/*pathology
EDAT- 2003/01/18 04:00
MHDA- 2003/05/21 05:00
CRDT- 2003/01/18 04:00
PHST- 2003/01/18 04:00 [pubmed]
PHST- 2003/05/21 05:00 [medline]
PHST- 2003/01/18 04:00 [entrez]
AID - 00434.2002 [pii]
AID - 10.1152/ajpregu.00434.2002 [doi]
PST - ppublish
SO  - Am J Physiol Regul Integr Comp Physiol. 2003 May;284(5):R1213-8. doi: 
      10.1152/ajpregu.00434.2002. Epub 2003 Jan 16.