PMID- 12535239
OWN - NLM
STAT- MEDLINE
DCOM- 20030307
LR  - 20220317
IS  - 1098-3015 (Print)
IS  - 1098-3015 (Linking)
VI  - 6
IP  - 1
DP  - 2003 Jan-Feb
TI  - Economic burden of long-term complications of deep vein thrombosis after total 
      hip replacement surgery in the United States.
PG  - 59-74
AB  - BACKGROUND: Estimates of the cost of long-term complications of a primary deep 
      vein thrombosis (DVT), including the post-thrombotic syndrome (PTS) and recurrent 
      venous thromboembolism (VTE), may be relevant for resource allocation decisions. 
      OBJECTIVE: The objective of this study was to provide US cost estimates of the 
      long-term complications of a primary DVT, which occurs in approximately 5% to 20% 
      (with adequate thromboprophylaxis) and 50% (in the absence of thromboprophylaxis) 
      of total hip replacement surgeries (THRS). METHODS: A literature-based model was 
      used to project the excess long-term complication costs of DVT following THRS. 
      The model simulated the natural history of DVT complications using published 
      estimates of the incidence and prognosis of PTS and recurrent VTE. Each 
      complication was assigned a cost obtained by multiplying the amount of resources 
      used in its management by the unit price of these resources. RESULTS: The annual 
      per-patient cost of each complication was as follows: mild-to-moderate PTS, 839 
      dollars in the first year and 341 dollars in subsequent years; severe PTS, 3817 
      dollars in the first year and 1677 dollars in subsequent years; DVT, 3798 
      dollars; and pulmonary embolism, 6604 dollars. The average discounted lifetime 
      cost of DVT complications was estimated to be 3069 dollars (95% interval 2091 
      dollars-4279 dollars). CONCLUSIONS: The long-term complications of a primary DVT 
      represent a significant economic burden. Preventing a DVT could arguably lead to 
      substantial savings in long-term DVT complications.
FAU - Caprini, Joseph A
AU  - Caprini JA
AD  - Evanston Northwestern Healthcare, Evanston, IL, USA.
FAU - Botteman, Marc F
AU  - Botteman MF
FAU - Stephens, Jennifer M
AU  - Stephens JM
FAU - Nadipelli, Vijay
AU  - Nadipelli V
FAU - Ewing, Mary M
AU  - Ewing MM
FAU - Brandt, Suzanne
AU  - Brandt S
FAU - Pashos, Chris L
AU  - Pashos CL
FAU - Cohen, Alexander T
AU  - Cohen AT
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Value Health
JT  - Value in health : the journal of the International Society for Pharmacoeconomics 
      and Outcomes Research
JID - 100883818
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Arthroplasty, Replacement, Hip/*adverse effects
MH  - Case-Control Studies
MH  - Cost Savings
MH  - *Cost of Illness
MH  - Female
MH  - Health Care Costs/*statistics & numerical data
MH  - Health Services Research
MH  - Humans
MH  - Incidence
MH  - Life Expectancy
MH  - Long-Term Care/economics
MH  - Male
MH  - Markov Chains
MH  - Models, Econometric
MH  - Monte Carlo Method
MH  - Prognosis
MH  - Quality-Adjusted Life Years
MH  - Recurrence
MH  - Sensitivity and Specificity
MH  - Severity of Illness Index
MH  - Survival Analysis
MH  - United States/epidemiology
MH  - Venous Thrombosis/*economics/epidemiology/*etiology/prevention & 
      control/psychology
EDAT- 2003/01/22 04:00
MHDA- 2003/03/08 04:00
CRDT- 2003/01/22 04:00
PHST- 2003/01/22 04:00 [pubmed]
PHST- 2003/03/08 04:00 [medline]
PHST- 2003/01/22 04:00 [entrez]
AID - S1098-3015(10)60133-7 [pii]
AID - 10.1046/j.1524-4733.2003.00204.x [doi]
PST - ppublish
SO  - Value Health. 2003 Jan-Feb;6(1):59-74. doi: 10.1046/j.1524-4733.2003.00204.x.