PMID- 12536027
OWN - NLM
STAT- MEDLINE
DCOM- 20030404
LR  - 20220311
IS  - 0387-7604 (Print)
IS  - 0387-7604 (Linking)
VI  - 25
IP  - 1
DP  - 2003 Jan
TI  - Virological and immunological aspects of seizure disorders.
PG  - 9-13
AB  - The brain is a symptom-producing organ, and one of the symptoms due to a basic 
      brain dysfunction is epilepsy. The pathophysiologic background is in most 
      epilepsies multifactorial, as different pre-, peri-, and postnatal triggers or 
      environmental conditions influence one or several genetic factors, where also 
      gender is of importance. One of the genetic factors is immunodysfunction, and the 
      trigger mechanism may be a virus infection. Viruses are the most common agents to 
      which the human being is exposed throughout life. The herpes virus group is of 
      special interest with respect to complications of the central nervous system. 
      Herpes viruses, especially herpes simplex virus type 1 (HSV-1), human herpes 
      virus type 6 (HHV-6), cytomegalovirus (CMV) and Epstein-Barr virus (EBV), are 
      capable of establishing latent infection and reactivating under a variety of 
      stimuli. In this review especially HHV-6 will be emphasized, as well as CMV in 
      relation to Rasmussen's syndrome. The immunological aspects will focus on 
      immunoglobulins, antibodies, especially the glutamate receptors, human leukocyte 
      antigens, T- and B-lymphocytes, and their respective interaction with the antigen 
      presenting cell. This course of events concerns the 'immunological synapse'. 
      Finally, reports on herpes virus genomes in the human brain are discussed. A 
      study on herpes viral DNA in brain tissue from patients operated for focal 
      epilepsy is briefly mentioned.
FAU - Eeg-Olofsson, Orvar
AU  - Eeg-Olofsson O
AD  - Department of Women's and Children's Health, Section for Pediatrics, Uppsala 
      University, S-751 85 Uppsala, Sweden.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Brain Dev
JT  - Brain & development
JID - 7909235
RN  - 0 (HLA Antigens)
RN  - 0 (Immunoglobulins)
RN  - 0 (Receptors, AMPA)
RN  - 0 (Receptors, Glutamate)
RN  - 0 (glutamate receptor ionotropic, AMPA 3)
SB  - IM
MH  - Brain/virology
MH  - Cytomegalovirus/metabolism
MH  - Epilepsy/blood/cerebrospinal fluid/genetics/*immunology/*virology
MH  - HLA Antigens/immunology
MH  - Herpesviridae Infections/*complications
MH  - Herpesvirus 1, Human/genetics
MH  - Herpesvirus 6, Human/metabolism
MH  - Humans
MH  - Immunoglobulins/blood/cerebrospinal fluid
MH  - Lymphocytes/immunology
MH  - Receptors, AMPA
MH  - Receptors, Glutamate/immunology
MH  - Roseolovirus Infections/complications
RF  - 61
EDAT- 2003/01/22 04:00
MHDA- 2003/04/05 05:00
CRDT- 2003/01/22 04:00
PHST- 2003/01/22 04:00 [pubmed]
PHST- 2003/04/05 05:00 [medline]
PHST- 2003/01/22 04:00 [entrez]
AID - S0387760402001626 [pii]
AID - 10.1016/s0387-7604(02)00162-6 [doi]
PST - ppublish
SO  - Brain Dev. 2003 Jan;25(1):9-13. doi: 10.1016/s0387-7604(02)00162-6.