PMID- 12536039
OWN - NLM
STAT- MEDLINE
DCOM- 20030328
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 337
IP  - 3
DP  - 2003 Feb 13
TI  - Short-term effects of 3,4-methylenedioximethamphetamine on noradrenergic activity 
      in locus coeruleus and hippocampus of the rat.
PG  - 123-6
AB  - This study was undertaken to investigate the effects of the administration of 
      3,4-methylenedioxymethamphetamine (MDMA) on the locus coeruleus firing rate, on 
      the sensitivity of the alpha(2)-adrenoceptors which regulate neuronal activity 
      and on the in vivo tyrosine hydroxylase activity in hippocampus. The basal firing 
      rate was not modified by either a single dose or repeated doses of MDMA, although 
      the latter produced a shift to the right in the dose-response curve for 
      clonidine-induced inhibition of the firing rate (ED(50) increased by 59%) and a 
      reduction in tyrosine hydroxylase activity (20%) in the hippocampus. However, 8 
      days after the final dose alpha(2)-adrenoceptor sensitivity and tyrosine 
      hydroxylase activity had returned to control values. Our results show a 
      desensitization of alpha(2)-adrenoceptors in locus coeruleus and the existence of 
      short-term changes in the noradrenergic system.
FAU - Arrue, Aurora
AU  - Arrue A
AD  - Department of Pharmacology, Faculty of Medicine and Odontology, University of the 
      Basque Country, 48940-Leioa, Vizcaya, Spain.
FAU - Ruiz-Ortega, Jose Angel
AU  - Ruiz-Ortega JA
FAU - Ugedo, Luisa
AU  - Ugedo L
FAU - Giralt, M Teresa
AU  - Giralt MT
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Adrenergic Uptake Inhibitors)
RN  - 0 (Adrenergic alpha-Agonists)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Receptors, Adrenergic, alpha-2)
RN  - 11F6O06WN0 (Brocresine)
RN  - 63-84-3 (Dihydroxyphenylalanine)
RN  - EC 1.14.16.2 (Tyrosine 3-Monooxygenase)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - MN3L5RMN02 (Clonidine)
RN  - R5J7E3L9SP (Fenclonine)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Adrenergic Uptake Inhibitors/*pharmacology
MH  - Adrenergic alpha-Agonists/pharmacology
MH  - Analysis of Variance
MH  - Animals
MH  - Brocresine/pharmacology
MH  - Clonidine/pharmacology
MH  - Dihydroxyphenylalanine/metabolism
MH  - Dose-Response Relationship, Drug
MH  - Electrophysiology
MH  - Enzyme Inhibitors/pharmacology
MH  - Fenclonine/pharmacology
MH  - Hippocampus/*drug effects/metabolism
MH  - Locus Coeruleus/*drug effects/metabolism
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Neurons/drug effects/metabolism
MH  - Norepinephrine/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Adrenergic, alpha-2/drug effects
MH  - Tyrosine 3-Monooxygenase/drug effects/metabolism
EDAT- 2003/01/22 04:00
MHDA- 2003/03/29 05:00
CRDT- 2003/01/22 04:00
PHST- 2003/01/22 04:00 [pubmed]
PHST- 2003/03/29 05:00 [medline]
PHST- 2003/01/22 04:00 [entrez]
AID - S0304394002012521 [pii]
AID - 10.1016/s0304-3940(02)01252-1 [doi]
PST - ppublish
SO  - Neurosci Lett. 2003 Feb 13;337(3):123-6. doi: 10.1016/s0304-3940(02)01252-1.