PMID- 12536308
OWN - NLM
STAT- MEDLINE
DCOM- 20030304
LR  - 20061115
IS  - 0945-6317 (Print)
IS  - 0945-6317 (Linking)
VI  - 442
IP  - 1
DP  - 2003 Jan
TI  - Molecular biology of laryngeal squamous cell carcinoma.
PG  - 1-7
AB  - Some of the mechanisms involved in neoplastic transformation and progression of 
      laryngeal squamous cell carcinoma (LSCC) are discussed. Although tumor suppressor 
      inactivation of p53 and p16 is common in these tumors (about 50% each), oncogenic 
      activation is less well characterized. Cyclin D1 and epidermal growth factor 
      receptor amplification have been reported in one-third and one-quarter of LSCCs, 
      respectively, both related to advanced stages, whereas c-myc could be amplified 
      in 13% of cases although without associated overexpression. The role of ras in 
      LSCC is, at most, exceptional, and the role of human papillomavirus infection in 
      these neoplasms could have been largely overestimated. The AIS (amplified in 
      squamous carcinoma) gene has been recently proposed as the main oncogenic target 
      in head and neck squamous carcinomas and is a promising line of investigation. 
      This, along with the link that exists between p53 and INK4 suppressor pathways 
      through ARF and MDM-2, and the role of the universal cdk inhibitors (the Cip/Kip 
      family) in these neoplasms deserve further investigation. Not forgotten are the 
      mechanisms leading to cell immortalization and invasive capabilities acquisition, 
      some of which are also briefly described.
FAU - Nadal, Alfons
AU  - Nadal A
AD  - Department of Anatomia Patologica, Hospital Clinic, Universitat de Barcelona, 
      Villarroel 170, 08036, Spain.
FAU - Cardesa, Antonio
AU  - Cardesa A
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20021112
PL  - Germany
TA  - Virchows Arch
JT  - Virchows Archiv : an international journal of pathology
JID - 9423843
RN  - 0 (DNA, Neoplasm)
RN  - 136601-57-5 (Cyclin D1)
RN  - EC 2.7.7.49 (Telomerase)
SB  - IM
MH  - Carcinoma, Squamous Cell/enzymology/*genetics/pathology
MH  - Cell Transformation, Neoplastic/genetics/pathology
MH  - Cyclin D1/genetics
MH  - DNA, Neoplasm/analysis
MH  - Disease Progression
MH  - Genes, p16
MH  - Genes, p53
MH  - Humans
MH  - Laryngeal Neoplasms/enzymology/*genetics/pathology
MH  - *Molecular Biology
MH  - Proto-Oncogenes
MH  - Telomerase
RF  - 71
EDAT- 2003/01/22 04:00
MHDA- 2003/03/05 04:00
CRDT- 2003/01/22 04:00
PHST- 2002/06/04 00:00 [received]
PHST- 2002/09/06 00:00 [accepted]
PHST- 2003/01/22 04:00 [pubmed]
PHST- 2003/03/05 04:00 [medline]
PHST- 2003/01/22 04:00 [entrez]
AID - 10.1007/s00428-002-0726-6 [doi]
PST - ppublish
SO  - Virchows Arch. 2003 Jan;442(1):1-7. doi: 10.1007/s00428-002-0726-6. Epub 2002 Nov 
      12.