PMID- 12536618
OWN - NLM
STAT- MEDLINE
DCOM- 20030505
LR  - 20151119
IS  - 1000-5625 (Print)
IS  - 1000-5625 (Linking)
VI  - 26
IP  - 1
DP  - 2001 Feb 28
TI  - [Level change of IL-10, IL-12 and TNF alpha in the serun of patients with 
      hepatocellular carcinoma].
PG  - 57-8
AB  - OBJECTIVE: To study the relationship and clinical significance between level 
      change of serum Interleukin 10 (IL-10), interleukin 12 (IL-12), tumor necrosis 
      factor-alpha (TNF alpha) and primary hepatic carcinoma (PHC). METHODS: Serum 
      IL-10, IL-12, TNF alpha in 40 patients with PHC, 36 cases with hepatocirrhosis 
      and 33 normal controls were measured with ELISA. RESULTS: The higher serum levels 
      of IL-10, IL-12, TNF alpha were observed in patients with hepatocirrhosis than in 
      controls (P < 0.01), although IL-12, TNF alpha in the serum of patients with PHC 
      were in the proximity of that of controls (P > 0.05), the IL-10 level was 
      significantly higher than that of control (P < 0.01), further more, IL-10 being 
      opposed to IL-12, TNF alpha is higher in patients with tumor above 5.0 cm in 
      diameter than below 5.0 cm, IL-12 and TNF alpha were declined and IL-10 increased 
      with tumor enlargement. CONCLUSION: The immune dysfunction in patients with PHC 
      may be related to level increase of IL-10. The level decrease of IL-12, TNF alpha 
      and increase of IL-10 is helpful to clinical differential diagnoses between 
      cirrhotic nodule and PHC, and this suggests cancerous tendency.
FAU - He, Y
AU  - He Y
AD  - Department of Oncology, Second Xangya Hospital, Central South University, 
      Changsha 410011.
FAU - Hu, C H
AU  - Hu CH
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Hunan Yi Ke Da Xue Xue Bao
JT  - Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical 
      University
JID - 9424769
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 130068-27-8 (Interleukin-10)
RN  - 187348-17-0 (Interleukin-12)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers, Tumor/blood
MH  - Carcinoma, Hepatocellular/blood
MH  - Female
MH  - Humans
MH  - Interleukin-10/*blood
MH  - Interleukin-12/*blood
MH  - Liver Cirrhosis/blood
MH  - Liver Neoplasms/*blood
MH  - Male
MH  - Middle Aged
MH  - Tumor Necrosis Factor-alpha/*metabolism
EDAT- 2003/01/23 04:00
MHDA- 2003/05/06 05:00
CRDT- 2003/01/23 04:00
PHST- 2003/01/23 04:00 [pubmed]
PHST- 2003/05/06 05:00 [medline]
PHST- 2003/01/23 04:00 [entrez]
PST - ppublish
SO  - Hunan Yi Ke Da Xue Xue Bao. 2001 Feb 28;26(1):57-8.