PMID- 12538043
OWN - NLM
STAT- MEDLINE
DCOM- 20030812
LR  - 20191106
IS  - 1567-5769 (Print)
IS  - 1567-5769 (Linking)
VI  - 3
IP  - 1
DP  - 2003 Jan
TI  - Anti-allergic action of buckwheat (Fagopyrum esculentum Moench) grain extract.
PG  - 129-36
AB  - The anti-allergic action of buckwheat grain extract (BGE) was investigated using 
      rodent experimental models. The oral, intraperitoneal and intradermal 
      administration of BGE significantly inhibited the compound 48/80-induced vascular 
      permeability documented by Evans blue extravasation. In addition, BGE showed 
      potent inhibitory effect on passive cutaneous anaphylaxis (PCA) activated by 
      anti-dinitrophenyl (DNP) IgE when orally administered. In an in vitro study, BGE 
      revealed to possess inhibitory potential on the compound 48/80-induced histamine 
      release from rat peritoneal mast cells (RPMC). Moreover, BGE inhibited the IL-4 
      and TNF-alpha mRNA induction by PMA and A23187 in human leukemia mast cells, 
      HMC-1. Taken together, these results suggest that anti-allergic action of BGE may 
      be due to the inhibition of histamine release and cytokine gene expression in the 
      mast cells.
CI  - Copyright 2002 Elsevier Science B.V.
FAU - Kim, Chang Deok
AU  - Kim CD
AD  - Oriental Hospital, Oriental Medical College of Daejeon University, 22-5 
      Daeheung-dong, Daejeon 301-724, South Korea.
FAU - Lee, Won-Kyung
AU  - Lee WK
FAU - No, Kyong-Ok
AU  - No KO
FAU - Park, Sang-Ki
AU  - Park SK
FAU - Lee, Min-Ho
AU  - Lee MH
FAU - Lim, Seok Rhin
AU  - Lim SR
FAU - Roh, Seok-Seon
AU  - Roh SS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Int Immunopharmacol
JT  - International immunopharmacology
JID - 100965259
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (Cytokines)
RN  - 0 (Plant Extracts)
RN  - 0 (RNA, Messenger)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
RN  - 820484N8I3 (Histamine)
SB  - IM
MH  - Animals
MH  - Anti-Allergic Agents/administration & dosage/chemistry/*pharmacology
MH  - Capillary Permeability/drug effects
MH  - Cell Line
MH  - Cytokines/genetics/metabolism
MH  - Fagopyrum/*chemistry
MH  - Histamine/metabolism
MH  - Humans
MH  - Male
MH  - Mast Cells/drug effects/metabolism
MH  - Passive Cutaneous Anaphylaxis/drug effects
MH  - Plant Extracts/administration & dosage/chemistry/*pharmacology
MH  - RNA, Messenger/genetics/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Seeds/*chemistry
MH  - p-Methoxy-N-methylphenethylamine/pharmacology
EDAT- 2003/01/23 04:00
MHDA- 2003/08/13 05:00
CRDT- 2003/01/23 04:00
PHST- 2003/01/23 04:00 [pubmed]
PHST- 2003/08/13 05:00 [medline]
PHST- 2003/01/23 04:00 [entrez]
AID - S1567-5769(02)00261-8 [pii]
AID - 10.1016/s1567-5769(02)00261-8 [doi]
PST - ppublish
SO  - Int Immunopharmacol. 2003 Jan;3(1):129-36. doi: 10.1016/s1567-5769(02)00261-8.