PMID- 12538662
OWN - NLM
STAT- MEDLINE
DCOM- 20030225
LR  - 20190508
IS  - 0022-1007 (Print)
IS  - 1540-9538 (Electronic)
IS  - 0022-1007 (Linking)
VI  - 197
IP  - 2
DP  - 2003 Jan 20
TI  - Unique resistance of I/LnJ mice to a retrovirus is due to sustained interferon 
      gamma-dependent production of virus-neutralizing antibodies.
PG  - 233-43
AB  - Selection of immune escape variants impairs the ability of the immune system to 
      sustain an efficient antiviral response and to control retroviral infections. 
      Like other retroviruses, mouse mammary tumor virus (MMTV) is not efficiently 
      eliminated by the immune system of susceptible mice. In contrast, MMTV-infected 
      I/LnJ mice are capable of producing IgG2a virus-neutralizing antibodies, sustain 
      this response throughout their life, and secrete antibody-coated virions into the 
      milk, thereby preventing infection of their progeny. Antibodies were produced in 
      response to several MMTV variants and were cross-reactive to them. Resistance to 
      MMTV infection was recessive and was dependent on interferon (IFN)-gamma 
      production, because I/LnJ mice with targeted deletion of the INF-gamma gene 
      failed to produce any virus-neutralizing antibodies. These findings reveal a 
      novel mechanism of resistance to retroviral infection that is based on a robust 
      and sustained IFN-gamma-dependent humoral immune response.
FAU - Purdy, Alexandra
AU  - Purdy A
AD  - The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
FAU - Case, Laure
AU  - Case L
FAU - Duvall, Melody
AU  - Duvall M
FAU - Overstrom-Coleman, Max
AU  - Overstrom-Coleman M
FAU - Monnier, Nilah
AU  - Monnier N
FAU - Chervonsky, Alexander
AU  - Chervonsky A
FAU - Golovkina, Tatyana
AU  - Golovkina T
LA  - eng
GR  - P30 CA034196/CA/NCI NIH HHS/United States
GR  - R01 CA089116/CA/NCI NIH HHS/United States
GR  - CA 34196/CA/NCI NIH HHS/United States
GR  - CA 89116/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (Antibodies, Viral)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Superantigens)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Antibodies, Viral/*biosynthesis
MH  - Cross Reactions
MH  - Female
MH  - Genetic Variation
MH  - Immunoglobulin G/biosynthesis
MH  - Interferon-gamma/*biosynthesis/deficiency/genetics
MH  - Mammary Glands, Animal/immunology/virology
MH  - Mammary Tumor Virus, Mouse/genetics/*immunology/pathogenicity
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C3H
MH  - Mice, Knockout
MH  - Milk/virology
MH  - Neutralization Tests
MH  - Retroviridae Infections/genetics/immunology/virology
MH  - Superantigens/genetics
MH  - Tumor Virus Infections/genetics/immunology/virology
PMC - PMC2193815
EDAT- 2003/01/23 04:00
MHDA- 2003/02/26 04:00
PMCR- 2003/07/20
CRDT- 2003/01/23 04:00
PHST- 2003/01/23 04:00 [pubmed]
PHST- 2003/02/26 04:00 [medline]
PHST- 2003/01/23 04:00 [entrez]
PHST- 2003/07/20 00:00 [pmc-release]
AID - 20021499 [pii]
AID - 10.1084/jem.20021499 [doi]
PST - ppublish
SO  - J Exp Med. 2003 Jan 20;197(2):233-43. doi: 10.1084/jem.20021499.