PMID- 12540596
OWN - NLM
STAT- MEDLINE
DCOM- 20030407
LR  - 20220408
IS  - 0012-1797 (Print)
IS  - 0012-1797 (Linking)
VI  - 52
IP  - 2
DP  - 2003 Feb
TI  - Sexual differentiation, pregnancy, calorie restriction, and aging affect the 
      adipocyte-specific secretory protein adiponectin.
PG  - 268-76
AB  - Adiponectin or adipocyte complement-related protein of 30 kDa (Acrp30) is a 
      circulating protein produced exclusively in adipocytes. Circulating Acrp30 levels 
      have been associated with insulin sensitivity in adult mice and humans, yet the 
      Acrp30 profile over the lifespan and its hormonal regulation in vivo have not 
      been previously described. Hence, we set forth to determine whether hormonal and 
      metabolic changes associated with sexual maturation, reproduction, aging, and 
      calorie restriction affect Acrp30. In mice, Acrp30 levels increase during sexual 
      maturation by 4-fold in males and 10-fold in females. Neonatal castration (CX) 
      allows Acrp30 of adults to reach female levels. CX in adults does not lead to 
      female Acrp30 levels unless glucocorticoid exposure is elevated simultaneously by 
      implant. Ovariectomy of infant mice does not interfere with the pubertal rise of 
      Acrp30. However, ovariectomy in adults increases Acrp30. Estrogen suppressed 
      Acrp30 in mice and 3T3-L1 adipocytes. In parallel to changes in estrogen action, 
      Acrp30 decreased in late gestation but increased in both calorie-restricted and 
      old (anovulatory) mice. The reduction of Acrp30 in lactating dams is consistent 
      with a suppressive effect of prolactin and a stimulating effect of bromocriptine. 
      In summary, Acrp30 levels in serum are under complex hormonal control and may 
      play a key role in determining systemic insulin sensitivity under the respective 
      conditions.
FAU - Combs, Terry P
AU  - Combs TP
AD  - Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York 
      10461, USA.
FAU - Berg, Anders H
AU  - Berg AH
FAU - Rajala, Michael W
AU  - Rajala MW
FAU - Klebanov, Simon
AU  - Klebanov S
FAU - Iyengar, Puneeth
AU  - Iyengar P
FAU - Jimenez-Chillaron, Jose C
AU  - Jimenez-Chillaron JC
FAU - Patti, Mary Elizabeth
AU  - Patti ME
FAU - Klein, Sabra L
AU  - Klein SL
FAU - Weinstein, Robert S
AU  - Weinstein RS
FAU - Scherer, Philipp E
AU  - Scherer PE
LA  - eng
GR  - 1R01-DK55758/DK/NIDDK NIH HHS/United States
GR  - F32 DK61228/DK/NIDDK NIH HHS/United States
GR  - R01-AR46191/AR/NIAMS NIH HHS/United States
GR  - T32 DK 07513-15/DK/NIDDK NIH HHS/United States
GR  - T32-GM07288/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Diabetes
JT  - Diabetes
JID - 0372763
RN  - 0 (Adiponectin)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Iodine Radioisotopes)
RN  - 0 (Proteins)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Adipocytes/*metabolism/*physiology
MH  - Adiponectin
MH  - Aging/*physiology
MH  - Animals
MH  - *Diet, Reducing
MH  - Female
MH  - *Intercellular Signaling Peptides and Proteins
MH  - Iodine Radioisotopes
MH  - Male
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Orchiectomy
MH  - Ovariectomy
MH  - Pregnancy
MH  - Pregnancy, Animal/*physiology
MH  - Proteins/genetics/*metabolism
MH  - RNA, Messenger/genetics
MH  - Rats
MH  - Rats, Long-Evans
MH  - *Sex Characteristics
MH  - Transcription, Genetic
EDAT- 2003/01/24 04:00
MHDA- 2003/04/08 05:00
CRDT- 2003/01/24 04:00
PHST- 2003/01/24 04:00 [pubmed]
PHST- 2003/04/08 05:00 [medline]
PHST- 2003/01/24 04:00 [entrez]
AID - 10.2337/diabetes.52.2.268 [doi]
PST - ppublish
SO  - Diabetes. 2003 Feb;52(2):268-76. doi: 10.2337/diabetes.52.2.268.