PMID- 12540968
OWN - NLM
STAT- MEDLINE
DCOM- 20040105
LR  - 20151119
IS  - 0340-6245 (Print)
IS  - 0340-6245 (Linking)
VI  - 89
IP  - 1
DP  - 2003 Jan
TI  - Vascular endothelial growth factor (VEGF-A) plasma levels in non-small cell lung 
      cancer: relationship with coagulation and platelet activation markers.
PG  - 177-84
AB  - Platelet activation, commonly found in lung cancer patients, may cause the 
      release of angiogenic factors, such as vascular endothelial growth factor 
      (VEGF-A). The present study was designed to investigate whether plasma VEGF-A 
      levels were associated to different stages of non-small cell lung cancer (NSCLC). 
      Moreover, sP-selectin, prothrombin fragment 1+2 (F1+2), thrombin-antithrombin III 
      complex (TATc) and D-dimer levels were measured to test the hypothesis of an 
      involvement of platelet and coagulation activation in tumor angiogenesis. VEGF-A, 
      sP-selectin, F1+2, TATc and D-dimer levels were elevated in 65 patients with 
      NSCLC, particularly in metastatic patients. sP-selectin (p <0.003) and F1+2 (p 
      <0.005) levels were independently associated to VEGF-A. In addition, patients 
      with positive levels of both sP-selectin and F1+2 had the highest levels of 
      VEGF-A. In conclusion, our findings support the hypothesis that thrombin 
      generation might induce platelet activation and VEGF-A release in NSCLC.
FAU - Roselli, Mario
AU  - Roselli M
AD  - Medical Oncology, Department of Surgry, University Tor Vergata, Rome, Italy.
FAU - Mineo, Tommaso C
AU  - Mineo TC
FAU - Basili, Stefania
AU  - Basili S
FAU - Mariotti, Sabrina
AU  - Mariotti S
FAU - Martini, Francesca
AU  - Martini F
FAU - Bellotti, Annamaria
AU  - Bellotti A
FAU - Ambrogi, Vincenzo
AU  - Ambrogi V
FAU - Spila, Antonella
AU  - Spila A
FAU - D'Alessandro, Roberta
AU  - D'Alessandro R
FAU - Gazzaniga, Pier Paolo
AU  - Gazzaniga PP
FAU - Guadagni, Fiorella
AU  - Guadagni F
FAU - Ferroni, Patrizia
AU  - Ferroni P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Thromb Haemost
JT  - Thrombosis and haemostasis
JID - 7608063
RN  - 0 (Biomarkers)
RN  - 0 (P-Selectin)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 2968PHW8QP (Citric Acid)
SB  - IM
MH  - Adenocarcinoma/blood
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/blood
MH  - Blood Coagulation
MH  - Carcinoma, Non-Small-Cell Lung/*blood/pathology
MH  - Case-Control Studies
MH  - Citric Acid
MH  - Female
MH  - Humans
MH  - *Lung Neoplasms
MH  - Male
MH  - Middle Aged
MH  - Neoplasms, Squamous Cell/blood
MH  - Neovascularization, Pathologic
MH  - P-Selectin/blood
MH  - Platelet Activation
MH  - Vascular Endothelial Growth Factor A/*blood
EDAT- 2003/01/24 04:00
MHDA- 2004/01/06 05:00
CRDT- 2003/01/24 04:00
PHST- 2003/01/24 04:00 [pubmed]
PHST- 2004/01/06 05:00 [medline]
PHST- 2003/01/24 04:00 [entrez]
AID - 03010177 [pii]
PST - ppublish
SO  - Thromb Haemost. 2003 Jan;89(1):177-84.