PMID- 12541256
OWN - NLM
STAT- MEDLINE
DCOM- 20030508
LR  - 20150525
IS  - 0740-3194 (Print)
IS  - 0740-3194 (Linking)
VI  - 49
IP  - 2
DP  - 2003 Feb
TI  - Simulations of thermal tissue coagulation and their value for the planning and 
      monitoring of laser-induced interstitial thermotherapy (LITT).
PG  - 351-62
AB  - MRI information is widely used for the monitoring of thermal therapies, such as 
      laser-induced interstitial thermotherapy (LITT). However, a detailed knowledge 
      about the relationship between time/temperature exposure and resulting tissue 
      thermal damage is needed to estimate the lesion extent. The aims of this work 
      were to model the thermal response of laser-irradiated tissue and to assess the 
      value of Monte Carlo simulation (MCS) for tumor therapy planning and monitoring. 
      MCS yielded true 3D distributions of laser-induced temperature and thermal 
      damage. These results were compared with 2D MR thermometry data from in vitro 
      experiments performed on animal liver tissue over an ordinary range of laser 
      powers (10-25 W) and irradiation times (5-25 min). Clinical reference data were 
      available from MR-guided liver LITT procedures. MCS correctly predicted the shape 
      of temperature and damage distributions. The quantitative agreement between 
      simulated and measured lesion diameters was within 10% and 15% for the in vitro 
      and in vivo cases, respectively. The simulated 53 degrees C isotherm best 
      estimated the boundary of the final thermal damage (6% variance). This study 
      shows that MCS of interstitial laser coagulation provides unique information that 
      can be of use in the empirical correlation of temperature with thermal damage, 
      and can assist greatly in thermal treatment planning and monitoring.
CI  - Copyright 2003 Wiley-Liss, Inc.
FAU - Puccini, Silvia
AU  - Puccini S
AD  - Department of Diagnostic Radiology, Leipzig University Hospital, Leipzig, 
      Germany.
FAU - Bar, Nils-Karsten
AU  - Bar NK
FAU - Bublat, Martin
AU  - Bublat M
FAU - Kahn, Thomas
AU  - Kahn T
FAU - Busse, Harald
AU  - Busse H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Magn Reson Med
JT  - Magnetic resonance in medicine
JID - 8505245
SB  - IM
MH  - Animals
MH  - Cattle
MH  - Computer Simulation
MH  - In Vitro Techniques
MH  - *Laser Coagulation
MH  - Liver/*pathology/surgery
MH  - Liver Neoplasms/*pathology/secondary/surgery
MH  - *Magnetic Resonance Imaging
MH  - Monte Carlo Method
MH  - Swine
EDAT- 2003/01/24 04:00
MHDA- 2003/05/09 05:00
CRDT- 2003/01/24 04:00
PHST- 2003/01/24 04:00 [pubmed]
PHST- 2003/05/09 05:00 [medline]
PHST- 2003/01/24 04:00 [entrez]
AID - 10.1002/mrm.10357 [doi]
PST - ppublish
SO  - Magn Reson Med. 2003 Feb;49(2):351-62. doi: 10.1002/mrm.10357.