PMID- 12541393
OWN - NLM
STAT- MEDLINE
DCOM- 20030708
LR  - 20201208
VI  - 13
IP  - 10
DP  - 1999 Oct
TI  - [The observation of mycology and clinical efficacy in 325 cases with otomycosis].
PG  - 438-40
AB  - OBJECTIVE: To study otomycosis of pathogenic fungi, antifungal susceptibility 
      test and clinical efficacy. METHOD: The study was performed as follows: 1) 
      culture of pathogenic fungi and fungus identification in 110 cases. 2) antifungal 
      susceptibility test with Etest strip by ketoconazole (KE), itraconazole (IT), 
      Fluconazole (FC), Fluorocytosine (FL), and amphotericinum B (AP). 3) Topical 
      application of doktarin ps cream (DC), ketoconazole cream (KEC), clotrimazole ung 
      (CU), and thymol alcohol (TA) were performed in 4 groups and the intermittent 
      impulsive treatment in who failed to respond to local treatment were performed 
      too. RESULT AND CONCLUSION: 1) Chiefly, otomycosis of pathogenic fungi were 
      aspergillus (79%) and candida albicans (8%) and penicillium citrinum (5%). 2) 
      Antifungal susceptibility test showed that aspergillus were sensitive to KE and 
      IT, but not sensitive to KE and FL, and candida albicans were sensitive to KE, 
      IT, FC, FL and AP all; P. citrinum was sensitive to AP, FL and KE but not to FC. 
      3) Effective rate of topical application on 4 groups were 97.6%, 97.5%, 90.0% and 
      80.0% respectively. Comparing the results between compound azoles drugs and TA, 
      there was a statistical significant difference (P < 0.05), the efficacy of 
      compound azoles is better than that of TA. The effective rate of systematic 
      intermittent impulsive treatment in 30 cases failed to respond to local treatment 
      were 100%.
FAU - Nong, H
AU  - Nong H
AD  - Otolaryngology of First Affiliated Hospital of Guangxi Medical University, 
      Nanning 530021.
FAU - Li, J
AU  - Li J
FAU - Huang, G
AU  - Huang G
FAU - Nong, D
AU  - Nong D
FAU - Cheng, P
AU  - Cheng P
FAU - Yao, C
AU  - Yao C
LA  - chi
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Ke Za Zhi
JT  - Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
JID - 9426080
RN  - 0 (Antifungal Agents)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Antifungal Agents/*administration & dosage/therapeutic use
MH  - Aspergillus/drug effects/isolation & purification
MH  - Candida albicans/drug effects/isolation & purification
MH  - Ear Diseases/*drug therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Microbial Sensitivity Tests
MH  - Middle Aged
MH  - Mycoses/*drug therapy
MH  - Penicillium/drug effects/isolation & purification
EDAT- 2003/01/25 04:00
MHDA- 2003/07/09 05:00
CRDT- 2003/01/25 04:00
PHST- 2003/01/25 04:00 [pubmed]
PHST- 2003/07/09 05:00 [medline]
PHST- 2003/01/25 04:00 [entrez]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Ke Za Zhi. 1999 Oct;13(10):438-40.