PMID- 12541682
OWN - NLM
STAT- MEDLINE
DCOM- 20030708
LR  - 20140625
VI  - 15
IP  - 3
DP  - 2001 Mar
TI  - [Herpesviridae and laryngeal neoplasia].
PG  - 122-4
AB  - OBJECTIVE: To investigate the relationship between herpesviridae and malignant or 
      benign laryngeal diseases. METHOD: 128 paraffin-embedded laryngeal squamous cell 
      carcinoma and laryngeal epithelium hyperplastic lesions were detected by 
      polymerase chain reaction (PCR) and PCR-ISH for herpesviridae. RESULT: HSV-1 was 
      detected in 10 cases by PCR, among them 3 were laryngeal squamous cell carcinoma 
      (LSCC), 1 was carcinoma in situ(CIS), 4 were laryngeal polyps and 2 were 
      laryngeal keratosis. Except 1 LSCC and 1 CIS 8 of 10 cases were positive while 
      detected by PCR-ISH. In benign diseases, signals were shown from basal layer to 
      superficial cell; in malignant lesions, the signals were scattered in the 
      diseases. CONCLUSION: Most of laryngeal diseases were not related to 
      herpesviridae, but HSV-1 may acts as initiator in the development of a few cases.
FAU - Lin, C
AU  - Lin C
AD  - Department of Otolaryngology, First Affiliated Hospital of Fujian Medical 
      University, Fuzhou 350005.
FAU - Jiang, S
AU  - Jiang S
FAU - Yang, W
AU  - Yang W
FAU - Han, D
AU  - Han D
FAU - Yi, Z
AU  - Yi Z
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Ke Za Zhi
JT  - Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
JID - 9426080
SB  - IM
MH  - Carcinoma, Squamous Cell/pathology/virology
MH  - Female
MH  - Herpesviridae/*isolation & purification
MH  - Herpesviridae Infections/*pathology
MH  - Herpesvirus 1, Human/isolation & purification
MH  - Humans
MH  - Laryngeal Diseases/*virology
MH  - Laryngeal Neoplasms/pathology/*virology
MH  - Male
MH  - Middle Aged
MH  - Polyps/virology
MH  - Precancerous Conditions/virology
EDAT- 2003/01/25 04:00
MHDA- 2003/07/09 05:00
CRDT- 2003/01/25 04:00
PHST- 2003/01/25 04:00 [pubmed]
PHST- 2003/07/09 05:00 [medline]
PHST- 2003/01/25 04:00 [entrez]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2001 Mar;15(3):122-4.