PMID- 12541904
OWN - NLM
STAT- MEDLINE
DCOM- 20031111
LR  - 20140625
VI  - 15
IP  - 8
DP  - 2001 Aug
TI  - [Detection of telomerase activity in laryngeal carcinoma and the association 
      between telomerase activity and lymphatic metastasis].
PG  - 360-2
AB  - OBJECTIVE: To investigate the telomerase activity in human laryngeal squamous 
      cell carcinomas (LSCC) and the association between telomerase activity and 
      lymphatic metastasis. METHOD: Telomerase activity was determined in 47 specimens 
      of LSCC and 10 specimens of laryngeal inflammatory polyps using PCR-ELISA. 
      RESULT: Telomerase activity was detected in 39 of 47 (83%) LSCC, but was not 
      detected in all 10 laryngeal inflammatory polyps. There were significant 
      differences between them (P < 0.01). Telomerase activation in LSCC with positive 
      cervical lymph node involvement appeared to be higher (13 out of 13 cases, 100%) 
      than in LSCC with negative cervical lymph node involvement (26 out of 34, 
      76.47%), (P < 0.05). CONCLUSION: Telomerase is activated frequently in LSCC and 
      may become a biomarker of LSCC. The detection of telomerase activity in LSCC may 
      have some value for predicting metastasis potential and prognosis and can guide 
      the clinical practices applying selective neck dissection.
FAU - Lu, Q
AU  - Lu Q
AD  - Department of Otorhinolaryngology, Anhui Provincial Hospital, Hefei 230001.
FAU - Lu, S
AU  - Lu S
FAU - Wang, M
AU  - Wang M
FAU - Ye, F
AU  - Ye F
FAU - Liu, R
AU  - Liu R
FAU - Zhu, H
AU  - Zhu H
FAU - Dai, H
AU  - Dai H
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Ke Za Zhi
JT  - Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology
JID - 9426080
RN  - EC 2.7.7.49 (Telomerase)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/*enzymology/secondary
MH  - Female
MH  - Humans
MH  - Laryngeal Neoplasms/*enzymology/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Telomerase/*metabolism
EDAT- 2003/01/25 04:00
MHDA- 2003/11/12 05:00
CRDT- 2003/01/25 04:00
PHST- 2003/01/25 04:00 [pubmed]
PHST- 2003/11/12 05:00 [medline]
PHST- 2003/01/25 04:00 [entrez]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2001 Aug;15(8):360-2.