PMID- 12542204
OWN - NLM
STAT- MEDLINE
DCOM- 20030410
LR  - 20071115
IS  - 0001-6489 (Print)
IS  - 0001-6489 (Linking)
VI  - 122
IP  - 8
DP  - 2002 Dec
TI  - Influence of human leukocyte antigen in the pathogenesis of Meniere's disease in 
      the South Korean population.
PG  - 851-6
AB  - In order to study the associations of Meniere's disease (MD) with human leukocyte 
      antigen (HLA) alleles in the South Korean population, we examined the 
      distribution of HLA class I and II alleles in 39 MD patients and 199 healthy 
      controls. The frequencies of HLA-Cw*0303 (relative risk (RR) = 2.5; p < 0.02) and 
      -Cw*0602 (RR = 3.7; p < 0.03) were significantly increased in patients with MD 
      compared to controls. However, HLA-B44 (RR = 0.2, p < 0.004) and -Cw*0102 (RR = 
      0.3; p < 0.03) were significantly decreased in patients compared to controls. 
      When the association between hearing level and the presence of HLA alleles was 
      evaluated, the frequencies of HLA-B13 (RR = 7.4; p < 0.004), -B39 (RR = 45.7; p < 
      0.003), -Cw*0303 (RR = 4.5; p < 0.02) and -Cw*0602 (RR = 6.5; p < 0.02) were 
      significantly increased and those of -B44 (RR = 0.1; p < 0.02) and -Cw*0102 (RR = 
      0.1; p < 0.03) were significantly decreased in MD patients with hearing losses 
      (stages II-IV) compared to controls. The frequency of HLA-B13 was significantly 
      higher in MD patients with hearing loss (stages II-IV) than in those with normal 
      hearing (stage I). In terms of HLA-DRB1, -DQA1 and -DQB1 allele frequencies, a 
      significantly higher frequency of DRB1*15 was seen in the patients (RR = 2.4; p < 
      0.03). These results suggest that some HLA alleles may be a useful genetic marker 
      for predicting prognosis in South Korean patients with MD.
FAU - Yeo, Sang W
AU  - Yeo SW
AD  - Department of Otolaryngology, College of Medicine, The Catholic University of 
      Korea, Seoul, South Korea.
FAU - Park, Shi-Nae
AU  - Park SN
FAU - Jeon, Eun-Ju
AU  - Jeon EJ
FAU - Lee, Heung-Youp
AU  - Lee HY
FAU - Pyo, Chul-Woo
AU  - Pyo CW
FAU - Kim, Tai-Gyu
AU  - Kim TG
LA  - eng
PT  - Journal Article
PL  - England
TA  - Acta Otolaryngol
JT  - Acta oto-laryngologica
JID - 0370354
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-D Antigens)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA Antigens/*analysis/genetics
MH  - HLA-A Antigens/analysis
MH  - HLA-B Antigens/analysis
MH  - HLA-C Antigens/genetics
MH  - HLA-D Antigens/genetics
MH  - Hearing Loss, Sensorineural/complications
MH  - Humans
MH  - Korea
MH  - Male
MH  - Meniere Disease/complications/*genetics/*immunology
MH  - Middle Aged
EDAT- 2003/01/25 04:00
MHDA- 2003/04/11 05:00
CRDT- 2003/01/25 04:00
PHST- 2003/01/25 04:00 [pubmed]
PHST- 2003/04/11 05:00 [medline]
PHST- 2003/01/25 04:00 [entrez]
PST - ppublish
SO  - Acta Otolaryngol. 2002 Dec;122(8):851-6.